Consequences on Islet and Incretin Hormone Responses to Dinner by Omission of Lunch in Healthy Men

Overview

Journal Endocrinol Diabetes Metab

Specialty Endocrinology

Date 2020 Jul 25

PMID 32704562

Citations 2

Authors

Ola Lindgren

Bo Ahren

Affiliations

Soon will be listed here.

Abstract

Background: Omission of breakfast results in higher glucose and lower insulin and incretin hormone levels after both lunch and dinner. Whether omission of lunch has a similar impact on the following meal is not known.

Aim: This study therefore explored whether omission of lunch ingestion affects glucose, islet and incretin hormones after dinner ingestion in healthy subjects.

Materials & Methods: Twelve male volunteers (mean age 22 years, BMI 22.5 kg/m) underwent two test days in random order with standard breakfast and dinner on both days with provision or omission of standard lunch in between.

Results: The results showed that throughout the 300 minutes study period, glucose, insulin, glucagon and GIP levels after dinner ingestion did not differ between the two tests. In contrast, C-peptide, and GLP-1 levels were 26%-35% higher at later time points after dinner ingestion when lunch had been omitted ( < .05).

Conclusion: We conclude that omission of lunch increases GLP-1 and insulin secretion and possibly also insulin clearance resulting in unchanged glucose and insulin levels after dinner ingestion.

Citing Articles

Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion in humans: Characteristics and regulation.

Alsalim W, Lindgren O, Ahren B J Diabetes Investig. 2022; 14(3):354-361.

PMID: 36539382 PMC: 9951578. DOI: 10.1111/jdi.13962.

Consequences on islet and incretin hormone responses to dinner by omission of lunch in healthy men.

Lindgren O, Ahren B Endocrinol Diabetes Metab. 2020; 3(3):e00141.

PMID: 32704562 PMC: 7375076. DOI: 10.1002/edm2.141.

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