Abnormal Liver Function Tests in Patients With COVID-19: Relevance and Potential Pathogenesis

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2020 Jul 24

PMID 32702162

Citations 141

Authors

Anna Bertolini

Ivo P Van de Peppel

Frank A J A Bodewes

Han Moshage

Alberto Fantin

Fabio Farinati

Romina Fiorotto

Johan W Jonker

Mario Strazzabosco

Henkjan J Verkade

Giulia Peserico

Affiliations

Soon will be listed here.

Citing Articles

Development and validation of a nomogram to assess the occurrence of liver dysfunction in patients with COVID-19 pneumonia in the ICU.

Wang Z, Zhao L, Xie K BMC Infect Dis. 2025; 25(1):332.

PMID: 40065225 PMC: 11892215. DOI: 10.1186/s12879-025-10684-1.

Pre-infection liver function is associated with all-cause mortality among hemodialysis patients with SARS-CoV-2 Omicron variant infection.

Zhang Q, Lu C, Wang H, Wu S, Jiang L, Li J Ren Fail. 2024; 46(2):2425069.

PMID: 39555696 PMC: 11574975. DOI: 10.1080/0886022X.2024.2425069.

Altered Liver Enzyme Markers in Patients with Asymptomatic, and Mild Omicron Infection: A Retrospective Study.

Cao X, Xie Y, Yi J, Liu Z, Han M, Duan J J Inflamm Res. 2024; 17:6875-6885.

PMID: 39372583 PMC: 11451451. DOI: 10.2147/JIR.S478812.

An Increase in Aspartate Aminotransferase Can Predict Worsening Disease Severity in Japanese Patients with COVID-19.

Matsumoto K, Nishida T, Nakamatsu D, Yamamoto M, Fukui K, Morimura O Clin Pract. 2024; 14(4):1601-1614.

PMID: 39194933 PMC: 11352687. DOI: 10.3390/clinpract14040129.

Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management.

Antar S, Ashour N, Hamouda A, Noreddin A, Al-Karmalawy A Inflammopharmacology. 2024; 32(5):2649-2680.

PMID: 39126569 DOI: 10.1007/s10787-024-01535-7.

References

Zhang B, Zhou X, Qiu Y, Song Y, Feng F, Feng J . Clinical characteristics of 82 cases of death from COVID-19. PLoS One. 2020; 15(7):e0235458. PMC: 7347130. DOI: 10.1371/journal.pone.0235458. View

Kredel M, Muellenbach R, Johannes A, Brederlau J, Roewer N, Wunder C . Hepatic effects of lung-protective pressure-controlled ventilation and a combination of high-frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury. Med Sci Monit. 2011; 17(10):BR275-81. PMC: 3539465. DOI: 10.12659/msm.881974. View

Wu Z, McGoogan J . Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. DOI: 10.1001/jama.2020.2648. View

Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W . A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579(7798):270-273. PMC: 7095418. DOI: 10.1038/s41586-020-2012-7. View

Zhang C, Shi L, Wang F . Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020; 5(5):428-430. PMC: 7129165. DOI: 10.1016/S2468-1253(20)30057-1. View

Qian G, Yang N, Ding F, Ma A, Shen Y, Shi C . Epidemiologic and clinical characteristics of 91 hospitalized patients with COVID-19 in Zhejiang, China: a retrospective, multi-centre case series. QJM. 2020; 113(7):474-481. PMC: 7184349. DOI: 10.1093/qjmed/hcaa089. View

Aziz M, Fatima R, Lee-Smith W, Assaly R . The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis. Crit Care. 2020; 24(1):255. PMC: 7249975. DOI: 10.1186/s13054-020-02995-3. View

Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D . Clinical Characteristics of Imported Cases of Coronavirus Disease 2019 (COVID-19) in Jiangsu Province: A Multicenter Descriptive Study. Clin Infect Dis. 2020; 71(15):706-712. PMC: 7108195. DOI: 10.1093/cid/ciaa199. View

Akhmerov A, Marban E . COVID-19 and the Heart. Circ Res. 2020; 126(10):1443-1455. DOI: 10.1161/CIRCRESAHA.120.317055. View

10.

Hajifathalian K, Kumar S, Newberry C, Shah S, Fortune B, Krisko T . Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City. Obesity (Silver Spring). 2020; 28(9):1606-1612. PMC: 7283831. DOI: 10.1002/oby.22923. View

11.

Michalakis K, Ilias I . SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes Metab Syndr. 2020; 14(4):469-471. PMC: 7189186. DOI: 10.1016/j.dsx.2020.04.033. View

12.

Gao F, Zheng K, Wang X, Sun Q, Pan K, Wang T . Obesity Is a Risk Factor for Greater COVID-19 Severity. Diabetes Care. 2020; 43(7):e72-e74. DOI: 10.2337/dc20-0682. View

13.

Ji D, Qin E, Xu J, Zhang D, Cheng G, Wang Y . Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study. J Hepatol. 2020; 73(2):451-453. PMC: 7141624. DOI: 10.1016/j.jhep.2020.03.044. View

14.

Wang Y, Liu S, Liu H, Li W, Lin F, Jiang L . SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020; 73(4):807-816. PMC: 7211738. DOI: 10.1016/j.jhep.2020.05.002. View

15.

Hernandez A, Roman Y, Pasupuleti V, Barboza J, White C . Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review. Ann Intern Med. 2020; 173(4):287-296. DOI: 10.7326/M20-2496. View

16.

De Smet V, Verhulst S, van Grunsven L . Single cell RNA sequencing analysis did not predict hepatocyte infection by SARS-CoV-2. J Hepatol. 2020; 73(4):993-995. PMC: 7253986. DOI: 10.1016/j.jhep.2020.05.030. View

17.

Cai Q, Huang D, Ou P, Yu H, Zhu Z, Xia Z . COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy. 2020; 75(7):1742-1752. DOI: 10.1111/all.14309. View

18.

Soeters P, Wolfe R, Shenkin A . Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN J Parenter Enteral Nutr. 2018; 43(2):181-193. PMC: 7379941. DOI: 10.1002/jpen.1451. View

19.

Weber S, Mayerle J, Irlbeck M, Gerbes A . Severe liver failure during SARS-CoV-2 infection. Gut. 2020; 69(7):1365-1367. DOI: 10.1136/gutjnl-2020-321350. View

20.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069. PMC: 7042881. DOI: 10.1001/jama.2020.1585. View