Insights into the Genetic Basis of in Atrial Fibrillation in a Chinese Han Population

Overview

Journal Cardiovasc Diagn Ther

Publisher AME Publishing Company

Specialty Cardiology & Vascular Diseases

Date 2020 Jul 23

PMID 32695619

Citations 1

Authors

Li Li

Yang Liu

Xinxin Li

Chunguang Qiu

Affiliations

Soon will be listed here.

Abstract

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia. High mobility group box 1 (HMGB1) has been demonstrated to be involved in AF, but the genetic relationship between them is not clear yet. Here, we investigated the genetic association between functional variants in and AF in a Chinese Han population.

Methods: Two common variants (the promoter one rs1045411 and the 3'UTR one rs1412125) in were selected and genotyped in 576 AF patients and 869 control subjects. Traditional risk factors, such as age, gender, the history of smoking, hypertension and diabetes mellitus, were adjusted as covariates using a logistic regression analysis (SPSS, v.21.0). The haplotypic analysis was performed using SPSS (v.21.0, Inc., Chicago, IL, USA).

Results: Under the allelic association analysis, neither rs1045411 nor rs1412125 was associated with AF with all P values >0.05; under the genotypic association analysis, the 3'UTR variant rs1045411 showed a marginally significant association with AF under the recessive model (P=0.056, OR =0.42; 95% CI: 0.17-1.02). When divided the studied population by gender, we still found no significant association results between the selected variants and AF with P values more than 0.05; however, when divided the population into subgroups by the age onset of AF, we found that the 3'UTR variant rs1045411 was significantly associated with AF in the late-onset subgroup (P=0.009, OR =11.1; 95% CI: 1.82-50.0).

Conclusions: The 3'UTR variant rs1045411 of might influence the risk of late-onset AF in the Chinese Han population, which provides an important target factor for the prevention and treatment study of AF.

Citing Articles

High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders.

Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M Cells. 2021; 10(10).

PMID: 34685561 PMC: 8533835. DOI: 10.3390/cells10102582.

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