Carneic Acids from an Endophytic Sp. As Dengue Virus Polymerase Inhibitors

Overview

Journal J Nat Prod

Date 2020 Jul 21

PMID 32686414

Citations 4

Authors

Laure-Anne Peyrat

Veronique Eparvier

Cecilia Eydoux

Jean-Claude Guillemot

Marc Litaudon

Didier Stien

Affiliations

Soon will be listed here.

Abstract

Thirteen carneic acids were isolated from the fungal endophyte sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds - were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC values in the 10 to 20 μM range without cytotoxicity. None inhibited Zika virus NS5 protein.

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