Epigenomic Programming in Early Fetal Brain Development

Overview

Journal Epigenomics

Specialty Genetics

Date 2020 Jul 18

PMID 32677466

Citations 4

Authors

Luolan Li

Cecile L Maire

Misha Bilenky

Annaick Carles

Alireza Heravi-Moussavi

Chibo Hong

Angela Tam

Baljit Kamoh

Stephanie Cho

Dorothy Cheung

Irene Li

Tina Wong

Raman P Nagarajan

Andrew J Mungall

Richard Moore

Ting Wang

Claudia L Kleinman

Nada Jabado

Steven Jm Jones

Marco A Marra

Keith L Ligon

Joseph F Costello

Martin Hirst

Affiliations

Soon will be listed here.

Abstract

To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation. We generated reference epigenomes and transcriptomes of dissected brain regions and primary neural progenitor cells (NPCs) derived from cortical and ganglionic eminence tissues of four normal human fetuses. Integration of these data across developmental stages revealed a directional increase in active regulatory states, transcription factor activities and gene transcription with developmental stage. Consistent with differences in their biology, NPCs derived from cortical and ganglionic eminence regions contained common, region specific, and gestational week specific regulatory states. We provide a high-resolution regulatory network for NPCs from different brain regions as a comprehensive reference for future studies.

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