Genetics of the RelB Locus in Escherichia Coli

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1977 Jul 1

PMID 326765

Citations 27

Authors

B Diderichsen

N P Fiil

R LAVALLE

Affiliations

Soon will be listed here.

Abstract

A mutant of Escherichia coli with a delayed relaxed phenotype very similar to that of a previously described relB mutant has been obtained using a new selection procedure. The mutation giving rise to this phenotype has been shown to map at 34.5 min and to be 12% cotransducible with man. It is recessive, revertible, and most likely an allele of the relB gene.

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References

Lennox E . Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955; 1(2):190-206. DOI: 10.1016/0042-6822(55)90016-7. View

ALFOELDI L, Stent G, Hoogs M, Hill R . PHYSIOLOGICAL EFFECTS OF THE RNA CONTROL (RC) GENE IN E. COLI. Z Vererbungsl. 1963; 94:285-302. DOI: 10.1007/BF00894773. View

Stent G, Brenner S . A genetic locus for the regulation of ribonucleic acid synthesis. Proc Natl Acad Sci U S A. 1961; 47:2005-14. PMC: 223254. DOI: 10.1073/pnas.47.12.2005. View

Leavitt R, Umbarger H . Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. J Bacteriol. 1962; 83:624-30. PMC: 279321. DOI: 10.1128/jb.83.3.624-630.1962. View

Fiil N, Willumsen B, Friesen J, von Meyenburg K . Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp. Mol Gen Genet. 1977; 150(1):87-101. DOI: 10.1007/BF02425329. View

Friesen J, Fiil N, Parker J, Haseltine W . A new relaxed mutant of Escherichia coli with an altered 50S ribosomal subunit. Proc Natl Acad Sci U S A. 1974; 71(9):3465-9. PMC: 433794. DOI: 10.1073/pnas.71.9.3465. View

Fiil N, von Meyenburg K, Friesen J . Accumulation and turnover of guanosine tetraphosphate in Escherichia coli. J Mol Biol. 1972; 71(3):769-83. DOI: 10.1016/s0022-2836(72)80037-8. View

Bachmann B, Low K, Taylor A . Recalibrated linkage map of Escherichia coli K-12. Bacteriol Rev. 1976; 40(1):116-67. PMC: 413944. DOI: 10.1128/br.40.1.116-167.1976. View

CASHEL M . Regulation of bacterial ppGpp and pppGpp. Annu Rev Microbiol. 1975; 29:301-18. DOI: 10.1146/annurev.mi.29.100175.001505. View

10.

Fill N . A functional analysis of the rel gene in Escherichia coli. J Mol Biol. 1969; 45(2):195-203. DOI: 10.1016/0022-2836(69)90099-0. View

11.

Martin R . Polarity in relaxed strains of Salmonella typhimurium. J Mol Biol. 1968; 31(1):127-34. DOI: 10.1016/0022-2836(68)90060-0. View

12.

CASHEL M, Gallant J . Two compounds implicated in the function of the RC gene of Escherichia coli. Nature. 1969; 221(5183):838-41. DOI: 10.1038/221838a0. View

13.

LAVALLE R . [New mutants for regulation of RNA synthesis]. Bull Soc Chim Biol (Paris). 1965; 47(8):1567-70. View

14.

Edlin G, MAALOE O . Synthesis and breakdown of messenger RNA without protein synthesis. J Mol Biol. 1966; 15(2):428-34. DOI: 10.1016/s0022-2836(66)80118-3. View

15.

Parker J, Watson R, Friesen J . A relaxed mutant with an altered ribosomal protein L11. Mol Gen Genet. 1976; 144(1):111-4. DOI: 10.1007/BF00277313. View