Multiple Toxin-antitoxin Systems in Mycobacterium Tuberculosis

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2014 Mar 26

PMID 24662523

Citations 138

Authors

Ambre Sala

Patricia Bordes

Pierre Genevaux

Affiliations

Soon will be listed here.

Abstract

The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease. To date, the cellular factors and the molecular mechanisms that mediate entry into the persistence phase are poorly understood. Remarkably, M. tuberculosis possesses a very high number of toxin-antitoxin (TA) systems in its chromosome, 79 in total, regrouping both well-known (68) and novel (11) families, with some of them being strongly induced in drug-tolerant persisters. In agreement with the capacity of stress-responsive TA systems to generate persisters in other bacteria, it has been proposed that activation of TA systems in M. tuberculosis could contribute to its pathogenesis. Herein, we review the current knowledge on the multiple TA families present in this bacterium, their mechanism, and their potential role in physiology and virulence.

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