The Effect of Acidic-treated Acorn Pollen on Lipid and Antioxidant Metabolism with Ovariectomized Rats

Overview

Journal Food Sci Biotechnol

Specialty Biotechnology

Date 2020 Jul 17

PMID 32670662

Authors

Su Jin Nam

Soo Im Chung

Mi Young Kang

Affiliations

Soon will be listed here.

Abstract

The hormonal imbalance that occurs during menopause increases the risk of aging and chronic diseases. Therefore, this study was intended to improve the health of menopause women by using pollen, which is a natural food, not drugs and hormones. Experiment I provided the supernatant of pollen vinegar extract with oral administration using ovariectomized rats. Experiment II used ovariectomized rats to provide pollen vinegar sediment mixed with the AIN-93 M diet and then looked into the effects on antioxidant and lipid metabolism. As a result, the intake of pollen controlled the lipid concentration and reduced the risk of arteriosclerosis. It inhibited the release of inflammable substances from hepatic and adipocyte tissues, and confirmed the anti-aging effect. These results indicated that pollen is effective in preventing obesity, metabolic diseases and aging after menopause.

References

Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin H . Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005; 105(5 Pt 1):1074-83. DOI: 10.1097/01.AOG.0000158865.98070.89. View

Lee J, Cho H, Jeong J, Lee M, Jeong Y, Shim K . New vinegar produced by tomato suppresses adipocyte differentiation and fat accumulation in 3T3-L1 cells and obese rat model. Food Chem. 2013; 141(3):3241-9. DOI: 10.1016/j.foodchem.2013.05.126. View

Lee Y, Lim W, Sung M . Carnosic Acid Modulates Increased Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Mice Fed Normal or High-Fat Diets. Nutrients. 2018; 10(12). PMC: 6315337. DOI: 10.3390/nu10121984. View

Toth M, Tchernof A, Sites C, Poehlman E . Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord. 2000; 24(2):226-31. DOI: 10.1038/sj.ijo.0801118. View

Ross R . Atherosclerosis--an inflammatory disease. N Engl J Med. 1999; 340(2):115-26. DOI: 10.1056/NEJM199901143400207. View

Newton K, Reed S, Grothaus L, Ehrlich K, Guiltinan J, Ludman E . The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas. 2005; 52(2):134-46. DOI: 10.1016/j.maturitas.2005.01.007. View

Noorafshan A, Dabbaghmanesh M, Tanideh N, Koohpeyma F, Rasooli R, Hajihoseini M . Stereological study of the effect of black olive hydroalcoholic extract on osteoporosis in vertebra and tibia in ovariectomized rats. Osteoporos Int. 2015; 26(9):2299-307. DOI: 10.1007/s00198-015-3126-x. View

Hsu C, Yen G . Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. J Agric Food Chem. 2007; 55(21):8404-10. DOI: 10.1021/jf071695r. View

Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M . Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II). JAMA. 2002; 288(1):49-57. DOI: 10.1001/jama.288.1.49. View

10.

Yamashita H, Fujisawa K, Ito E, Idei S, Kawaguchi N, Kimoto M . Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biosci Biotechnol Biochem. 2007; 71(5):1236-43. DOI: 10.1271/bbb.60668. View

11.

Paglia D, Valentine W . Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1):158-69. View

12.

Block G, Sinha R, Gridley G . Collection of dietary-supplement data and implications for analysis. Am J Clin Nutr. 1994; 59(1 Suppl):232S-239S. DOI: 10.1093/ajcn/59.1.232S. View

13.

Havel P . Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol. 2002; 13(1):51-9. DOI: 10.1097/00041433-200202000-00008. View

14.

Tatsimo S, Tamokou J, Havyarimana L, Csupor D, Forgo P, Hohmann J . Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Res Notes. 2012; 5:158. PMC: 3353177. DOI: 10.1186/1756-0500-5-158. View

15.

Holst D, Grimaldi P . New factors in the regulation of adipose differentiation and metabolism. Curr Opin Lipidol. 2002; 13(3):241-5. DOI: 10.1097/00041433-200206000-00002. View

16.

Stubbins R, Holcomb V, Hong J, Nunez N . Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance. Eur J Nutr. 2011; 51(7):861-70. DOI: 10.1007/s00394-011-0266-4. View

17.

Georgiev D, Metka M, Huber J, Goudev A, Manassiev N . Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trial. MedGenMed. 2005; 6(4):46. PMC: 1480585. View

18.

Liu X, Zhang F, Zhou B, Shan H, Chen P . Effect of sonication on different quality parameters of Pinus massoniana pollen. Ultrason Sonochem. 2014; 22:174-81. DOI: 10.1016/j.ultsonch.2014.07.010. View

19.

Saric A, Balog T, Sobocanec S, Kusic B, Sverko V, Rusak G . Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. Food Chem Toxicol. 2009; 47(3):547-54. DOI: 10.1016/j.fct.2008.12.007. View

20.

Mackness M, Arrol S, Durrington P . Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 1991; 286(1-2):152-4. DOI: 10.1016/0014-5793(91)80962-3. View