Gli1 Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation

Overview

Journal Stem Cell Reports

Publisher Cell Press

Specialty Cell Biology

Date 2020 Jul 16

PMID 32668219

Citations 18

Authors

Ji Chen

Meng Li

An-Qi Liu

Chen-Xi Zheng

Li-Hui Bao

Kai Chen

Xiao-Lin Xu

Jiang-Tao Guan

Meng Bai

Tao Zhou

Bing-Dong Sui

De-Hua Li

Yan Jin

Cheng-Hu Hu

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem/stromal cells (MSCs) reside in the perivascular niche and modulate tissue/organ homeostasis; however, little is known about whether and how their localization and function are linked. Particularly, whether specific MSC subsets couple with and regulate specialized vessel subtypes is unclear. Here, we show that Gli1 cells, which are a subpopulation of MSCs couple with and regulate a specialized form of vasculature. The specific capillaries, i.e., CD31EMCN type H vessels, are the preferable vascular subtype which Gli1 cells are adjacent to in bone. Gli1 cells are further identified to be phenotypically coupled with type H endothelium during bone growth and defect healing. Importantly, Gli1 cell ablation inhibits type H vessel formation associated with suppressed bone generation and regeneration. Mechanistically, Gli1 cells initiate angiogenesis through Gli and HIF-1α signaling. These findings suggest a morphological and functional framework of Gli1 cells modulating coupled type H vasculature for tissue homeostasis and regenerative repair.

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