Instructive Role of the Vascular Niche in Promoting Tumour Growth and Tissue Repair by Angiocrine Factors

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 Jan 23

PMID 20094048

Citations 295

Authors

Jason M Butler

Hideki Kobayashi

Shahin Rafii

Affiliations

Soon will be listed here.

Abstract

The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

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