The Emerging Landscape of Circular RNAs in Immunity: Breakthroughs and Challenges

Overview

Journal Biomark Res

Publisher Biomed Central

Date 2020 Jul 16

PMID 32665846

Citations 15

Authors

Zhouxiao Li

Ye Cheng

Fan Wu

Liangliang Wu

Hongyong Cao

Qian Wang

Weiwei Tang

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-throughput sequencing advancement has been developing, functional circRNAs have been increasingly recognized, and more extensive analyses expounded their effect on different diseases. However, the study on the function of circRNAs in the immune system remains insufficient. This study discusses the basic principles of circRNAs regulation and the systems involved in physiology-related and pathology-related processes. The effect of circRNAs on immune regulation is elucidated. The ongoing development of circRNAs and basic immunology has multiplied their potential in treating diseases. Such perspective will summarize the status and effect of circRNAs on various immune cells in cancer, autoimmune diseases and infections. Moreover, this study will primarily expound the system of circRNAs in T lymphocytes, macrophages and other immune cells, which creates a novel perspective and lay a theoretical basis for treating diseases.

Citing Articles

Circular RNAs in cancer.

Guo Y, Huang Q, Heng Y, Zhou Y, Chen H, Xu C MedComm (2020). 2025; 6(2):e70079.

PMID: 39901896 PMC: 11788016. DOI: 10.1002/mco2.70079.

Hsa_circ_0109623 regulates the progression of autoimmune liver disease through Hsa_miR_146b-3p/Sortilin 1-mediated activation of CD4+ T cells.

Lv X, Zhu L, Feng S, Yang S, Li G, Zhan J Hepatol Commun. 2025; 9(1.

PMID: 39774281 PMC: 11717529. DOI: 10.1097/HC9.0000000000000607.

Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.

Zhang Q, Zhang H, Feng S, Yao M, Ding J, Li X Redox Biol. 2024; 79():103449.

PMID: 39647239 PMC: 11667058. DOI: 10.1016/j.redox.2024.103449.

Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.

Mahmoudi E, Khavari B, Cairns M Int J Mol Sci. 2024; 25(22).

PMID: 39596524 PMC: 11594334. DOI: 10.3390/ijms252212459.

Recent Progress of CircRNAs in Hematological Malignancies.

Cui Y, Wang L, Xu J, Nan H, Yang P, Niu J Int J Med Sci. 2024; 21(13):2544-2561.

PMID: 39439468 PMC: 11492881. DOI: 10.7150/ijms.98156.

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