The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos During Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Jul 16

PMID 32664640

Citations 2

Authors

Pier Mario Biava

Affiliations

Soon will be listed here.

Abstract

Studies conducted on Zebrafish embryos in our laboratory have allowed for the identification of precise moments of organogenesis in which a lot of genes are switched on and off, a sign that the genome is undergoing substantial changes in gene expression. Stem cell growth and differentiation stage-factors present in different moments of organogenesis have proven to have different specific functions in gene regulation. The substances present in the first stages of cell differentiation in Zebrafish embryos have demonstrated an ability to counteract the senescence of stem cells, reducing the expression of the beta-galactosidase marker, enhancing the genes , , , , and the transcription of Bmi-1, which act as key telomerase-independent repressors of cell aging. The molecules present in the intermediate to late stages of cell differentiation have proven to be able to reprogram pathological human cells, such as cancer cells and those of the basal layer of the epidermis in psoriasis, which present a higher multiplication rate than normal cells. The factors present in all the stages of cell differentiation are able to counteract neurodegeneration, and to regenerate tissues: It has been possible to regenerate hair follicles in many patients with androgenetic alopecia through transdermal administration of stem cell differentiation stage factors (SCDSFs) by means of cryopass-laser.

Citing Articles

Cell Therapy for Androgenetic Alopecia: Elixir or Trick?.

Mao Y, Liu P, Wei J, Xie Y, Zheng Q, Li R Stem Cell Rev Rep. 2023; 19(6):1785-1799.

PMID: 37277541 PMC: 10390634. DOI: 10.1007/s12015-023-10532-2.

Long-Term Transcriptomic Changes and Cardiomyocyte Hyperpolyploidy after Lactose Intolerance in Neonatal Rats.

Anatskaya O, Runov A, Ponomartsev S, Vonsky M, Elmuratov A, Vinogradov A Int J Mol Sci. 2023; 24(8).

PMID: 37108224 PMC: 10138443. DOI: 10.3390/ijms24087063.

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