Cell Therapy for Androgenetic Alopecia: Elixir or Trick?

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2023 Jun 5

PMID 37277541

Authors

Yongcui Mao

Pinyan Liu

Jiayun Wei

Ye Xie

Qiuxia Zheng

Rui Li

Jia Yao

Affiliations

Soon will be listed here.

Abstract

Androgenetic alopecia is the most common cause of hair loss aggravated by increased life pressure, tension, and anxiety. Although androgenetic alopecia (AGA) does not significantly effect physical health, it can have serious negative impact on the mental health and quality of life of the patient. Currently, the effect of medical treatment for AGA is not idealistic, stem cell-based regenerative medicine has shown potential for hair regrowth and follicle repair, but the long-term effect and mechanism of stem cell therapy is not quite explicit. In this review, we summarize the methods, efficacy, mechanism, and clinical progress of stem cell therapies for AGA by now, hope it will present a more comprehensive view in this topic.

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References

Wang L, Siegenthaler J, Dowell R, Yi R . Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science. 2016; 351(6273):613-7. PMC: 4828140. DOI: 10.1126/science.aad5440. View

Morinaga H, Mohri Y, Grachtchouk M, Asakawa K, Matsumura H, Oshima M . Obesity accelerates hair thinning by stem cell-centric converging mechanisms. Nature. 2021; 595(7866):266-271. PMC: 9600322. DOI: 10.1038/s41586-021-03624-x. View

Jo H, Brito S, Kwak B, Park S, Lee M, Bin B . Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation. Int J Mol Sci. 2021; 22(5). PMC: 7957487. DOI: 10.3390/ijms22052410. View

Salem A, Ibrahim H, Abdelaziz H, Elsaie M . Implications of cigarette smoking on early-onset androgenetic alopecia: A cross-sectional Study. J Cosmet Dermatol. 2020; 20(4):1318-1324. DOI: 10.1111/jocd.13727. View

Jung M, Ha S, Huh S, Park S, Kim S, Yang Y . Hair-growth stimulation by conditioned medium from vitamin D3-activated preadipocytes in C57BL/6 mice. Life Sci. 2015; 128:39-46. DOI: 10.1016/j.lfs.2015.02.018. View

Redler S, Brockschmidt F, Tazi-Ahnini R, Drichel D, Birch M, Dobson K . Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss. Br J Dermatol. 2012; 166(6):1314-8. DOI: 10.1111/j.1365-2133.2012.10877.x. View

Inui S, Itami S . Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla. J Dermatol Sci. 2010; 61(1):1-6. DOI: 10.1016/j.jdermsci.2010.10.015. View

Heo J, Kim S, Yang C, Choi Y, Song S, Kim H . Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing. Tissue Eng Regen Med. 2021; 18(4):537-548. PMC: 8325736. DOI: 10.1007/s13770-020-00316-x. View

Gherardini J, Wegner J, Cheret J, Ghatak S, Lehmann J, Alam M . Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine. Int J Cosmet Sci. 2019; 41(2):164-182. PMC: 6850087. DOI: 10.1111/ics.12521. View

10.

Ho B, Ho E, Chu C, Ramasamy S, Bigliardi-Qi M, de Sessions P . Microbiome in the hair follicle of androgenetic alopecia patients. PLoS One. 2019; 14(5):e0216330. PMC: 6499469. DOI: 10.1371/journal.pone.0216330. View

11.

Uitto J . Genetic Susceptibility to Alopecia. N Engl J Med. 2019; 380(9):873-876. DOI: 10.1056/NEJMe1900042. View

12.

Di Santo R, Romano S, Mazzini A, Jovanovic S, Nocca G, Campi G . Recent Advances in the Label-Free Characterization of Exosomes for Cancer Liquid Biopsy: From Scattering and Spectroscopy to Nanoindentation and Nanodevices. Nanomaterials (Basel). 2021; 11(6). PMC: 8230295. DOI: 10.3390/nano11061476. View

13.

Liu W, Li K, Wang G, Yang L, Qu Q, Fan Z . Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen. J Dermatol. 2020; 48(3):289-300. DOI: 10.1111/1346-8138.15672. View

14.

Hamilton J . Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci. 1951; 53(3):708-28. DOI: 10.1111/j.1749-6632.1951.tb31971.x. View

15.

Chew E, Tan J, Bahta A, Ho B, Liu X, Lim T . Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia. J Invest Dermatol. 2016; 136(8):1559-1567. DOI: 10.1016/j.jid.2016.03.032. View

16.

Lachgar S, Charveron M, Gall Y, Bonafe J . Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br J Dermatol. 1998; 138(3):407-11. DOI: 10.1046/j.1365-2133.1998.02115.x. View

17.

Mahe Y, Cheniti A, Tacheau C, Antonelli R, Planard-Luong L, de Bernard S . Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity. Lasers Surg Med. 2021; 53(9):1208-1219. PMC: 9292036. DOI: 10.1002/lsm.23398. View

18.

Joseph A, Baiju I, Bhat I, Pandey S, Bharti M, Verma M . Mesenchymal stem cell-conditioned media: A novel alternative of stem cell therapy for quality wound healing. J Cell Physiol. 2020; 235(7-8):5555-5569. DOI: 10.1002/jcp.29486. View

19.

Gentile P, Garcovich S . Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy. Int J Mol Sci. 2020; 21(8). PMC: 7216252. DOI: 10.3390/ijms21082702. View

20.

Suchonwanit P, Thammarucha S, Leerunyakul K . Minoxidil and its use in hair disorders: a review. Drug Des Devel Ther. 2019; 13:2777-2786. PMC: 6691938. DOI: 10.2147/DDDT.S214907. View