» Articles » PMID: 32661106

Hyperglycemia But Not Hyperinsulinemia Is Favorable for Exercise in Type 1 Diabetes: A Pilot Study

Overview
Journal Diabetes Care
Specialty Endocrinology
Date 2020 Jul 15
PMID 32661106
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Objective: To distinguish the effects of hyperglycemia and hyperinsulinemia on exercise-induced increases in R and endogenous glucose production (EGP) in type 1 diabetes.

Research Design And Methods: We studied six participants without diabetes and six participants with type 1 diabetes on three visits in random order for the following: euglycemia, low insulin (EuLoI); euglycemia, high insulin (EuHiI); and hyperglycemia, low insulin (HyLoI). Glucose fluxes were measured using [6,6-H] glucose before, during, and after 60 min of exercise.

Results: R increased ( < 0.01) with exercise within groups, while peak R during exercise was lower ( < 0.01) in participants with type 1 diabetes than participants without diabetes during all visits. In type 1 diabetes participants, EGP increased ( < 0.001) with exercise during EuLoI and HyLoI but not during EuHiI. This demonstrates that hyperinsulinemia, but not hyperglycemia, blunts the compensatory exercise-induced increase in EGP in type 1 diabetes.

Conclusions: The data from this pilot study indicate that ) exercise-induced compensatory increase in EGP was inhibited in participants with type 1 diabetes with hyperinsulinemia but not with hyperglycemia; ) in contrast, in participants without diabetes, exercise-induced increase in EGP was inhibited only during combined hyperinsulinemia and hyperglycemia. Taken together, these results suggest that low insulin coupled with euglycemia or modest hyperglycemia appear to be the most favorable milieu for type 1 diabetes during exercise.

Citing Articles

Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes.

Romeres D, Yadav Y, Ruchi F, Carter R, Cobelli C, Basu R J Clin Endocrinol Metab. 2024; 109(9):e1720-e1731.

PMID: 38174728 PMC: 11318997. DOI: 10.1210/clinem/dgae005.


New model of glucose-insulin regulation characterizes effects of physical activity and facilitates personalized treatment evaluation in children and adults with type 1 diabetes.

Deichmann J, Bachmann S, Burckhardt M, Pfister M, Szinnai G, Kaltenbach H PLoS Comput Biol. 2023; 19(2):e1010289.

PMID: 36791144 PMC: 9974135. DOI: 10.1371/journal.pcbi.1010289.


The endocrine pancreas during exercise in people with and without type 1 diabetes: Beyond the beta-cell.

McCarthy O, Schmidt S, Christensen M, Bain S, Norgaard K, Bracken R Front Endocrinol (Lausanne). 2022; 13:981723.

PMID: 36147573 PMC: 9485437. DOI: 10.3389/fendo.2022.981723.


Acute effects of the food preservative propionic acid on glucose metabolism in humans.

Adler G, Hornik E, Murray G, Bhandari S, Yadav Y, Heydarpour M BMJ Open Diabetes Res Care. 2021; 9(1).

PMID: 34312159 PMC: 8314753. DOI: 10.1136/bmjdrc-2021-002336.


Exercise effect on insulin-dependent and insulin-independent glucose utilization in healthy individuals and individuals with type 1 diabetes: a modeling study.

Romeres D, Schiavon M, Basu A, Cobelli C, Basu R, Dalla Man C Am J Physiol Endocrinol Metab. 2021; 321(1):E122-E129.

PMID: 33998292 PMC: 8321821. DOI: 10.1152/ajpendo.00084.2021.


References
1.
Rizza R, Mandarino L, Gerich J . Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol. 1981; 240(6):E630-9. DOI: 10.1152/ajpendo.1981.240.6.E630. View

2.
Shetty V, Fournier P, Davey R, Retterath A, Paramalingam N, Roby H . Effect of Exercise Intensity on Glucose Requirements to Maintain Euglycemia During Exercise in Type 1 Diabetes. J Clin Endocrinol Metab. 2016; 101(3):972-80. DOI: 10.1210/jc.2015-4026. View

3.
Chimen M, Kennedy A, Nirantharakumar K, Pang T, Andrews R, Narendran P . What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia. 2011; 55(3):542-51. DOI: 10.1007/s00125-011-2403-2. View

4.
Steele R, Wall J, DE BODO R, ALTSZULER N . Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol. 1956; 187(1):15-24. DOI: 10.1152/ajplegacy.1956.187.1.15. View

5.
Mallad A, Hinshaw L, Schiavon M, Dalla Man C, Dadlani V, Basu R . Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach. Am J Physiol Endocrinol Metab. 2015; 308(12):E1106-15. PMC: 4469811. DOI: 10.1152/ajpendo.00014.2015. View