The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2020 Jul 14

PMID 32655968

Citations 26

Authors

Hanbyeul Choi

Heonju Song

Yong Woo Jung

Affiliations

Soon will be listed here.

Abstract

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.

Citing Articles

A novel anti-mouse CCR7 monoclonal antibody, CMab-7, demonstrates high sensitivity in flow cytometry, western blot, and immunohistochemistry.

Satofuka H, Suzuki H, Tanaka T, Ubukata R, Hirose M, Yamamoto H Biochem Biophys Rep. 2025; 41:101948.

PMID: 40028039 PMC: 11870228. DOI: 10.1016/j.bbrep.2025.101948.

Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma.

Leshem R, Sefton K, Wong C, Lin I, Isaac D, Niepel M J Immunother Cancer. 2025; 13(1).

PMID: 39870492 PMC: 11772928. DOI: 10.1136/jitc-2024-010683.

Peripheral immune characteristics and subset disorder in reproductive females with endometriosis.

Lin K, Li P, Zhu X, Mao X, Peng J, Chen X Front Immunol. 2024; 15:1431175.

PMID: 39669572 PMC: 11634862. DOI: 10.3389/fimmu.2024.1431175.

CAR T-cells for pediatric solid tumors: where to go from here?.

Trautmann T, Yakobian N, Nguyen R Cancer Metastasis Rev. 2024; 43(4):1445-1461.

PMID: 39317919 PMC: 11554711. DOI: 10.1007/s10555-024-10214-6.

Fueling CARs: metabolic strategies to enhance CAR T-cell therapy.

Van der Vreken A, Vanderkerken K, de Bruyne E, de Veirman K, Breckpot K, Menu E Exp Hematol Oncol. 2024; 13(1):66.

PMID: 38987856 PMC: 11238373. DOI: 10.1186/s40164-024-00535-1.

References

Maude S, Frey N, Shaw P, Aplenc R, Barrett D, Bunin N . Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014; 371(16):1507-17. PMC: 4267531. DOI: 10.1056/NEJMoa1407222. View

Yeon S, Choi A, Hong M, Jung Y . Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases. Arch Pharm Res. 2019; 42(9):754-765. DOI: 10.1007/s12272-019-01159-4. View

Burgstahler R, Kempkes B, Steube K, Lipp M . Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2. Biochem Biophys Res Commun. 1995; 215(2):737-43. DOI: 10.1006/bbrc.1995.2525. View

Johnson E, Cole G . Functional heterogeneity of lymphocytic choriomeningitis virus-specfic T lymphocytes. I. Identification of effector amd memory subsets. J Exp Med. 1975; 141(4):866-81. PMC: 2189749. View

Dauner J, Williams I, Jacob J . Differential microenvironment localization of effector and memory CD8 T cells. J Immunol. 2007; 180(1):291-9. DOI: 10.4049/jimmunol.180.1.291. View

Kallies A, Xin A, Belz G, Nutt S . Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity. 2009; 31(2):283-95. DOI: 10.1016/j.immuni.2009.06.021. View

Okada T, Cyster J . CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol. 2007; 178(5):2973-8. DOI: 10.4049/jimmunol.178.5.2973. View

Gebhardt T, Wakim L, Eidsmo L, Reading P, Heath W, Carbone F . Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol. 2009; 10(5):524-30. DOI: 10.1038/ni.1718. View

Khanna K, McNamara J, Lefrancois L . In situ imaging of the endogenous CD8 T cell response to infection. Science. 2007; 318(5847):116-20. PMC: 2846662. DOI: 10.1126/science.1146291. View

10.

Ngo V, Tang H, Cyster J . Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med. 1998; 188(1):181-91. PMC: 2525549. DOI: 10.1084/jem.188.1.181. View

11.

Kanegane H, Tosato G . Activation of naive and memory T cells by interleukin-15. Blood. 1996; 88(1):230-5. View

12.

Sallusto F, Kremmer E, Palermo B, Hoy A, Ponath P, Qin S . Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol. 1999; 29(6):2037-45. DOI: 10.1002/(SICI)1521-4141(199906)29:06<2037::AID-IMMU2037>3.0.CO;2-V. View

13.

Kim M, Ouyang W, Liao W, Zhang M, Li M . The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity. 2013; 39(2):286-97. PMC: 3809840. DOI: 10.1016/j.immuni.2013.07.013. View

14.

Worbs T, Mempel T, Bolter J, von Andrian U, Forster R . CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007; 204(3):489-95. PMC: 2137901. DOI: 10.1084/jem.20061706. View

15.

Chuang C, Pan M, Hou M, Hung W . Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. J Cell Physiol. 2012; 228(2):341-8. DOI: 10.1002/jcp.24136. View

16.

Porter D, Levine B, Kalos M, Bagg A, June C . Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011; 365(8):725-33. PMC: 3387277. DOI: 10.1056/NEJMoa1103849. View

17.

Debes G, Arnold C, Young A, Krautwald S, Lipp M, Hay J . Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol. 2005; 6(9):889-94. PMC: 2144916. DOI: 10.1038/ni1238. View

18.

TJonck W, Guilliams M, Bonnardel J . Niche signals and transcription factors involved in tissue-resident macrophage development. Cell Immunol. 2018; 330:43-53. PMC: 6108424. DOI: 10.1016/j.cellimm.2018.02.005. View

19.

Shin H, Iwasaki A . A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature. 2012; 491(7424):463-7. PMC: 3499630. DOI: 10.1038/nature11522. View

20.

Ng O, Chia A, Tan A, Jadi R, Leong H, Bertoletti A . Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016; 34(17):2008-14. PMC: 7115611. DOI: 10.1016/j.vaccine.2016.02.063. View