Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases Via Functioning As an MiRNA Sponge

Overview

Journal Mol Ther Methods Clin Dev

Publisher Cell Press

Date 2020 Jul 9

PMID 32637451

Citations 50

Authors

Shuyue Ren

Peirong Lin

Jingrong Wang

Haoying Yu

Tingting Lv

Lan Sun

Guanhua Du

Affiliations

Soon will be listed here.

Abstract

Circular RNAs (circRNAs) are a new class of noncoding single-stranded RNAs that differ from linear microRNAs (miRNAs), since they form covalently closed loop structures without free 3' poly(A) tails or 5' caps. circRNAs are the competitive endogenous RNAs (ceRNAs) by binding to miRNA through miRNA response elements (MREs) (i.e., "miRNA sponge"), thereby reducing the quantity of miRNA available to target mRNA, subsequently promoting mRNA stability or protein expression, which involves the initiation and progress of human diseases. Owing to these features of abundance, stability, conservative property, and tissue and stage specificity, widely distributing in the extracellular space and in various bodily fluids, circRNAs can be considered as potential biomarkers for various diseases. Here, we reviewed the promising circRNAs being disease biomarkers, focused on their regulatory function by acting as miRNA sponges, and described their roles in cancer, cardiovascular or neurodegenerative diseases, osteoarthritis, rheumatoid arthritis, diabetes, and other human aging-related diseases, which provide a new direction for pathogenesis, diagnosis, and treatment of human aging-related diseases.

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References

Wang X, Zhu X, Zhang H, Wei S, Chen Y, Chen Y . Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation. Biochem Biophys Res Commun. 2018; 496(4):1069-1075. DOI: 10.1016/j.bbrc.2018.01.126. View

Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y . Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. EBioMedicine. 2017; 27:18-26. PMC: 5828303. DOI: 10.1016/j.ebiom.2017.12.007. View

Shan K, Liu C, Liu B, Chen X, Dong R, Liu X . Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. Circulation. 2017; 136(17):1629-1642. DOI: 10.1161/CIRCULATIONAHA.117.029004. View

Tian F, Yu C, Ye W, Wang Q . Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. Biochem Biophys Res Commun. 2017; 493(3):1260-1266. DOI: 10.1016/j.bbrc.2017.09.136. View

Nie W, Zhao L, Guo R, Wang M, Ye F . Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma. Eur Rev Med Pharmacol Sci. 2018; 22(19):6239-6244. DOI: 10.26355/eurrev_201810_16030. View

Yang R, Xing L, Zheng X, Sun Y, Wang X, Chen J . The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression. Mol Cancer. 2019; 18(1):4. PMC: 6325825. DOI: 10.1186/s12943-018-0933-7. View

Lei K, Bai H, Wei Z, Xie C, Wang J, Li J . The mechanism and function of circular RNAs in human diseases. Exp Cell Res. 2018; 368(2):147-158. DOI: 10.1016/j.yexcr.2018.05.002. View

Zhang R, Xu J, Zhao J, Wang X . Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells. Eur Rev Med Pharmacol Sci. 2018; 22(1):118-126. DOI: 10.26355/eurrev_201801_14108. View

Ashwal-Fluss R, Meyer M, Pamudurti N, Ivanov A, Bartok O, Hanan M . circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014; 56(1):55-66. DOI: 10.1016/j.molcel.2014.08.019. View

10.

Zhao J, Zou H, Han C, Ma J, Zhao J, Tang J . Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis. Cell Cycle. 2018; 17(24):2731-2744. PMC: 6343738. DOI: 10.1080/15384101.2018.1556058. View

11.

Liu X, Yang Y, Liu X, Zhang M, Li R, Yin Y . A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma. J Transl Med. 2019; 17(1):50. PMC: 6380039. DOI: 10.1186/s12967-019-1800-z. View

12.

Li M, Ding W, Sun T, Tariq M, Xu T, Li P . Biogenesis of circular RNAs and their roles in cardiovascular development and pathology. FEBS J. 2017; 285(2):220-232. DOI: 10.1111/febs.14191. View

13.

Liu Z, Zhou Y, Liang G, Ling Y, Tan W, Tan L . Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death Dis. 2019; 10(2):55. PMC: 6343010. DOI: 10.1038/s41419-018-1287-1. View

14.

Ji Q, Zhang C, Sun X, Li Q . Circular RNAs function as competing endogenous RNAs in multiple types of cancer. Oncol Lett. 2018; 15(1):23-30. PMC: 5768103. DOI: 10.3892/ol.2017.7348. View

15.

Chen Y, Li C, Tan C, Liu X . Circular RNAs: a new frontier in the study of human diseases. J Med Genet. 2016; 53(6):359-65. DOI: 10.1136/jmedgenet-2016-103758. View

16.

Poliseno L, Salmena L, Zhang J, Carver B, Haveman W, Pandolfi P . A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010; 465(7301):1033-8. PMC: 3206313. DOI: 10.1038/nature09144. View

17.

Lu L, Sun J, Shi P, Kong W, Xu K, He B . Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Oncotarget. 2017; 8(27):44096-44107. PMC: 5546465. DOI: 10.18632/oncotarget.17307. View

18.

Yang F, Zhu P, Guo J, Liu X, Wang S, Wang G . Circular RNAs in thoracic diseases. J Thorac Dis. 2018; 9(12):5382-5389. PMC: 5757001. DOI: 10.21037/jtd.2017.10.143. View

19.

Sun H, Xi P, Sun Z, Wang Q, Zhu B, Zhou J . Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression. Cancer Manag Res. 2018; 10:5725-5734. PMC: 6248399. DOI: 10.2147/CMAR.S172592. View

20.

Tang C, Zhang M, Huang L, Hu Z, Zhu J, Xiao Z . CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep. 2017; 7:40342. PMC: 5228128. DOI: 10.1038/srep40342. View