A Hybrid Model for Predicting Bone Healing Around Dental Implants

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2020 Jul 8

PMID 32630583

Citations 2

Authors

Pei-Ching Kung

Shih-Shun Chien

Nien-Ti Tsou

Affiliations

Soon will be listed here.

Abstract

Background: The effect of the short-term bone healing process is typically neglected in numerical models of bone remodeling for dental implants. In this study, a hybrid two-step algorithm was proposed to enable a more accurate prediction for the performance of dental implants.

Methods: A mechano-regulation algorithm was firstly used to simulate the tissue differentiation around a dental implant during the short-term bone healing. Then, the result was used as the initial state of the bone remodeling model to simulate the long-term healing of the bones. The algorithm was implemented by a 3D finite element model.

Results: The current hybrid model reproduced several features which were discovered in the experiments, such as stress shielding effect, high strength bone connective tissue bands, and marginal bone loss. A reasonable location of bone resorptions and the stability of the dental implant is predicted, compared with those predicted by the conventional bone remodeling model.

Conclusions: The hybrid model developed here predicted bone healing processes around dental implants more accurately. It can be used to study bone healing before implantation surgery and assist in the customization of dental implants.

Citing Articles

Biomechanics of Osseointegration of a Dental Implant in the Mandible Under Shock Wave Therapy: In Silico Study.

Smolin A, Eremina G, Martyshina I, Xie J Materials (Basel). 2025; 17(24.

PMID: 39769804 PMC: 11677247. DOI: 10.3390/ma17246204.

Prediction of Bone Healing around Dental Implants in Various Boundary Conditions by Deep Learning Network.

Kung P, Hsu C, Yang A, Chen N, Tsou N Int J Mol Sci. 2023; 24(3).

PMID: 36768272 PMC: 9915893. DOI: 10.3390/ijms24031948.

Special Issue: Dental Implant Materials 2019.

Yeo I Materials (Basel). 2020; 13(24).

PMID: 33352980 PMC: 7766183. DOI: 10.3390/ma13245790.

References

Ammon C, Kreutz M, Rehli M, Krause S, Andreesen R . Platelets induce monocyte differentiation in serum-free coculture. J Leukoc Biol. 1998; 63(4):469-76. DOI: 10.1002/jlb.63.4.469. View

Chou H, Romanos G, Muftu A, Muftu S . Peri-implant bone remodeling around an extraction socket: predictions of bone maintenance by finite element method. Int J Oral Maxillofac Implants. 2012; 27(4):e39-48. View

Provatidis C . A comparative FEM-study of tooth mobility using isotropic and anisotropic models of the periodontal ligament. Finite Element Method. Med Eng Phys. 2000; 22(5):359-70. DOI: 10.1016/s1350-4533(00)00055-2. View

Carter D, Hayes W . The compressive behavior of bone as a two-phase porous structure. J Bone Joint Surg Am. 1977; 59(7):954-62. View

Turner C, Anne V, Pidaparti R . A uniform strain criterion for trabecular bone adaptation: do continuum-level strain gradients drive adaptation?. J Biomech. 1997; 30(6):555-63. DOI: 10.1016/s0021-9290(97)84505-8. View

Lian Z, Guan H, Ivanovski S, Loo Y, Johnson N, Zhang H . Effect of bone to implant contact percentage on bone remodelling surrounding a dental implant. Int J Oral Maxillofac Surg. 2010; 39(7):690-8. DOI: 10.1016/j.ijom.2010.03.020. View

Carter D . Mechanical loading histories and cortical bone remodeling. Calcif Tissue Int. 1984; 36 Suppl 1:S19-24. DOI: 10.1007/BF02406129. View

Huiskes R, Weinans H, Grootenboer H, Dalstra M, Fudala B, Slooff T . Adaptive bone-remodeling theory applied to prosthetic-design analysis. J Biomech. 1987; 20(11-12):1135-50. DOI: 10.1016/0021-9290(87)90030-3. View

Jansen V, Conrads G, Richter E . Microbial leakage and marginal fit of the implant-abutment interface. Int J Oral Maxillofac Implants. 1997; 12(4):527-40. View

10.

Papalexiou V, Novaes Jr A, Grisi M, Souza S, Taba Jr M, Kajiwara J . Influence of implant microstructure on the dynamics of bone healing around immediate implants placed into periodontally infected sites. A confocal laser scanning microscopic study. Clin Oral Implants Res. 2004; 15(1):44-53. DOI: 10.1111/j.1600-0501.2004.00995.x. View

11.

Hadjidakis D, Androulakis I . Bone remodeling. Ann N Y Acad Sci. 2007; 1092:385-96. DOI: 10.1196/annals.1365.035. View

12.

Reina J, Garcia-Aznar J, Dominguez J, Doblare M . Numerical estimation of bone density and elastic constants distribution in a human mandible. J Biomech. 2006; 40(4):828-36. DOI: 10.1016/j.jbiomech.2006.03.007. View

13.

Carter D, Fyhrie D, Whalen R . Trabecular bone density and loading history: regulation of connective tissue biology by mechanical energy. J Biomech. 1987; 20(8):785-94. DOI: 10.1016/0021-9290(87)90058-3. View

14.

Lin D, Li Q, Li W, Swain M . Bone remodeling induced by dental implants of functionally graded materials. J Biomed Mater Res B Appl Biomater. 2009; 92(2):430-8. DOI: 10.1002/jbm.b.31531. View

15.

Zohar R, Cheifetz S, McCulloch C, Sodek J . Analysis of intracellular osteopontin as a marker of osteoblastic cell differentiation and mesenchymal cell migration. Eur J Oral Sci. 1998; 106 Suppl 1:401-7. DOI: 10.1111/j.1600-0722.1998.tb02206.x. View

16.

Huiskes R, Weinans H, van Rietbergen B . The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. Clin Orthop Relat Res. 1992; (274):124-34. View

17.

Frost H . Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol. 2003; 275(2):1081-101. DOI: 10.1002/ar.a.10119. View

18.

Hart R, Davy D, HEIPLE K . A computational method for stress analysis of adaptive elastic materials with a view toward applications in strain-induced bone remodeling. J Biomech Eng. 1984; 106(4):342-50. DOI: 10.1115/1.3138503. View

19.

Ghiasi M, Chen J, Vaziri A, Rodriguez E, Nazarian A . Bone fracture healing in mechanobiological modeling: A review of principles and methods. Bone Rep. 2017; 6:87-100. PMC: 5365304. DOI: 10.1016/j.bonr.2017.03.002. View

20.

Perez M, Prendergast P . Random-walk models of cell dispersal included in mechanobiological simulations of tissue differentiation. J Biomech. 2006; 40(10):2244-53. DOI: 10.1016/j.jbiomech.2006.10.020. View