Type 5 Phosphodiesterase (PDE5) and the Vascular Tree: From Embryogenesis to Aging and Disease

Overview

Journal Mech Ageing Dev

Specialty Geriatrics

Date 2020 Jul 7

PMID 32628940

Citations 11

Authors

Valeriana Cesarini

Eugenia Guida

Federica Campolo

Clara Crescioli

Angela Di Baldassarre

Calogera Pisano

Carmela Rita Balistreri

Giovanni Ruvolo

Emmanuele A Jannini

Susanna Dolci

Affiliations

Soon will be listed here.

Abstract

Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.

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