Movement Initiation and Grasp Representation in Premotor and Primary Motor Cortex Mirror Neurons

Overview

Journal Elife

Specialty Biology

Date 2020 Jul 7

PMID 32628107

Citations 10

Authors

Steven Jack Jerjian

Maneesh Sahani

Alexander Kraskov

Affiliations

Soon will be listed here.

Abstract

Pyramidal tract neurons (PTNs) within macaque rostral ventral premotor cortex (F5) and (M1) provide direct input to spinal circuitry and are critical for skilled movement control. Contrary to initial hypotheses, they can also be active during action observation, in the absence of any movement. A population-level understanding of this phenomenon is currently lacking. We recorded from single neurons, including identified PTNs, in (M1) (n = 187), and F5 (n = 115) as two adult male macaques executed, observed, or withheld (NoGo) reach-to-grasp actions. F5 maintained a similar representation of grasping actions during both execution and observation. In contrast, although many individual M1 neurons were active during observation, M1 population activity was distinct from execution, and more closely aligned to NoGo activity, suggesting this activity contributes to withholding of self-movement. M1 and its outputs may dissociate initiation of movement from representation of grasp in order to flexibly guide behaviour.

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