Cyclophilin D: An Integrator of Mitochondrial Function

Overview

Journal Front Physiol

Date 2020 Jul 7

PMID 32625108

Citations 47

Authors

Georgios Amanakis

Elizabeth Murphy

Affiliations

Soon will be listed here.

Abstract

Cyclophilin D (CypD) is a mitochondrial peptidyl-prolyl cis-trans isomerase, well-known for regulating the mitochondrial permeability transition pore (PTP), a nonspecific large conductance pore whose opening leads to cell death and has been implicated in ischemia/reperfusion injury in multiple organs, in neurodegenerative disorders, and in muscular dystrophies. While the main target of CypD is a matter of ongoing research, inhibiting CypD protects in models of those diseases making it an interesting therapeutic target. The present review focuses on post-translational modifications of CypD that have been identified by recent studies, which can alter the regulation of the PTP and contribute to understanding the mechanisms of action of CypD.

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