Regulation of Autophagy by Non-Steroidal Anti-Inflammatory Drugs in Cancer

Overview

Journal Cancer Manag Res

Publisher Dove Medical Press

Specialty Oncology

Date 2020 Jul 2

PMID 32606952

Citations 6

Authors

Xiangjie Fu

Tan Tan

Peijun Liu

Affiliations

Soon will be listed here.

Abstract

Cancer is the leading cause of death, placing a substantial global health burden. The development of the most effective treatment regimen is the unmet clinical need for cancer. Inflammation plays a role in tumorigenesis and progression, and anti-inflammation may be a promising option for cancer management and prevention. Emerging studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) display anticarcinogenic and chemopreventive properties through the regulation of autophagy in certain types of cancer. In this review, we summarize the pharmacological functions and side effects of NSAIDs as chemotherapeutic agents, and focus on its mode of action on autophagy regulation, which increases our knowledge of NSAIDs and cancer-related inflammation, and contributes to a putative addition of NSAIDs in the chemoprevention and treatment of cancer.

Citing Articles

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References

Kondo Y, Kanzawa T, Sawaya R, Kondo S . The role of autophagy in cancer development and response to therapy. Nat Rev Cancer. 2005; 5(9):726-34. DOI: 10.1038/nrc1692. View

Crighton D, Wilkinson S, OPrey J, Syed N, Smith P, Harrison P . DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 2006; 126(1):121-34. DOI: 10.1016/j.cell.2006.05.034. View

Hill S, Wrobel L, Rubinsztein D . Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation. Cell Death Differ. 2018; 26(4):617-629. PMC: 6460389. DOI: 10.1038/s41418-018-0254-9. View

Domiati S, El-Mallah A, Ghoneim A, Bekhit A, El Razik H . Evaluation of anti-inflammatory, analgesic activities, and side effects of some pyrazole derivatives. Inflammopharmacology. 2016; 24(4):163-72. DOI: 10.1007/s10787-016-0270-7. View

Singh S, Vats S, Chia A, Tan T, Deng S, Ong M . Dual role of autophagy in hallmarks of cancer. Oncogene. 2017; 37(9):1142-1158. DOI: 10.1038/s41388-017-0046-6. View

Mazzanti R, Platini F, Bottini C, Fantappie O, Solazzo M, Tessitore L . Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. Biochem Pharmacol. 2009; 78(1):21-32. DOI: 10.1016/j.bcp.2009.03.013. View

Silva J, Arantes-Rodrigues R, Pinto-Leite R, Faustino-Rocha A, Fidalgo-Goncalves L, Santos L . Synergistic Effect of Carboplatin and Piroxicam on Two Bladder Cancer Cell Lines. Anticancer Res. 2017; 37(4):1737-1745. DOI: 10.21873/anticanres.11506. View

Bauvy C, Gane P, Arico S, Codogno P, Ogier-Denis E . Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29. Exp Cell Res. 2001; 268(2):139-49. DOI: 10.1006/excr.2001.5285. View

Qi L, Ye J, Xue W, Tian X, Zhang H . [The mechanism of aspirin combined with metformin induced apoptosis of thyroid cancer TPC-1 cells]. Zhonghua Zhong Liu Za Zhi. 2019; 41(4):276-281. DOI: 10.3760/cma.j.issn.0253-3766.2019.04.006. View

10.

Yue W, Yang C, DiPaola R, Tan X . Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila). 2014; 7(4):388-97. DOI: 10.1158/1940-6207.CAPR-13-0337. View

11.

Yao M, Zhou W, Sangha S, Albert A, Chang A, Liu T . Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. Clin Cancer Res. 2005; 11(4):1618-28. DOI: 10.1158/1078-0432.CCR-04-1696. View

12.

Bhat P, Kriel J, Shubha Priya B, Basappa , Shivananju N, Loos B . Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization. Biochem Pharmacol. 2017; 147:170-182. DOI: 10.1016/j.bcp.2017.11.021. View

13.

Rabinowitz J, White E . Autophagy and metabolism. Science. 2010; 330(6009):1344-8. PMC: 3010857. DOI: 10.1126/science.1193497. View

14.

Hua H, Zhang H, Kong Q, Wang J, Jiang Y . Complex roles of the old drug aspirin in cancer chemoprevention and therapy. Med Res Rev. 2018; 39(1):114-145. DOI: 10.1002/med.21514. View

15.

Moon H, Park S, Lee S, Kang C, Kim S . Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation. Oncol Res. 2019; 27(7):835-847. PMC: 7848457. DOI: 10.3727/096504019X15517850319579. View

16.

Zhang Z, Chen F, Shang L . Advances in antitumor effects of NSAIDs. Cancer Manag Res. 2018; 10:4631-4640. PMC: 6197827. DOI: 10.2147/CMAR.S175212. View

17.

Olejniczak-Keder A, Szarynska M, Wronska A, Siedlecka-Kroplewska K, Kmiec Z . Effects of 5-FU and anti-EGFR antibody in combination with ASA on the spherical culture system of HCT116 and HT29 colorectal cancer cell lines. Int J Oncol. 2019; 55(1):223-242. DOI: 10.3892/ijo.2019.4809. View

18.

Avivi D, Moshkowitz M, Detering E, Arber N . The role of low-dose aspirin in the prevention of colorectal cancer. Expert Opin Ther Targets. 2012; 16 Suppl 1:S51-62. DOI: 10.1517/14728222.2011.647810. View

19.

Diaz-Gonzalez F, Sanchez-Madrid F . NSAIDs: learning new tricks from old drugs. Eur J Immunol. 2014; 45(3):679-86. PMC: 5065088. DOI: 10.1002/eji.201445222. View

20.

Gao M, Yeh P, Lu Y, Hsu C, Chen K, Lee W . OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res. 2008; 68(22):9348-57. DOI: 10.1158/0008-5472.CAN-08-1642. View