2,5-dimethyl Celecoxib Induces Apoptosis and Autophagy Via Activation of ROS/JNK Axis in Nasopharyngeal Carcinoma Cells

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Sep 13

PMID 34511433

Citations 1

Authors

Tan Tan

Xiangjie Fu

Jiaquan Qu

Miao Zhang

He Chen

Yaochun Wang

Bo Wang

Juan Li

Jie Liu

Peijun Liu

Affiliations

Soon will be listed here.

Abstract

2,5-dimethyl celecoxib (DMC), a close derivative of celecoxib, has also been reported to have anticancer effects. However, the effects and underlying molecular mechanisms of DMC with respect to nasopharyngeal carcinoma are still largely unknown. In this study, we present that DMC has displayed anticancer potency in nasopharyngeal carcinoma and . Mechanistically, we found DMC induced apoptosis and autophagy for anticancer therapy against nasopharyngeal carcinoma. Furthermore, DMC-induced autophagy could remarkably attenuate after the treatment of reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and c-Jun N-terminal kinase (JNK) inhibitor SP600125 (SP). Taken together, these results suggested DMC induced apoptosis and autophagic death via activation of ROS/JNK axis in NPC cells, which providing us new insights into developing potential therapeutic agents for nasopharyngeal carcinoma patients.

Citing Articles

Knockdown of LAMB3 suppressed radioresistance in nasopharyngeal carcinoma via deactivating NRF2 signaling pathway.

Zhuang Q, Liu G, Huang W, He Z J Radiat Res. 2023; 64(3):509-519.

PMID: 36947579 PMC: 10214995. DOI: 10.1093/jrr/rrad014.

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