Reducing Senescent Cell Burden in Aging and Disease

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2020 Jun 27

PMID 32589933

Citations 78

Authors

Robert J Pignolo

Joao F Passos

Sundeep Khosla

Tamara Tchkonia

James L Kirkland

Affiliations

Soon will be listed here.

Abstract

Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric syndromes, multimorbidity, and accelerated aging phenotypes. In animals, genetic and pharmacologic reduction of senescent cell burden results in the prevention, delay, and/or alleviation of a variety of aging-related diseases and sequelae. Early clinical trials have thus far focused on safety and target engagement of senolytic agents that clear senescent cells. We hypothesize that these pharmacologic interventions may have transformative effects on geriatric medicine.

Citing Articles

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