Layer 4 Gates Plasticity in Visual Cortex Independent of a Canonical Microcircuit

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2020 Jun 27

PMID 32589913

Citations 8

Authors

Michael G Frantz

Emily C Crouse

Guela Sokhadze

Taruna Ikrar

Celeste-Elise Stephany

Collins Nguyen

Xiangmin Xu

Aaron W McGee

Affiliations

Soon will be listed here.

Abstract

Disrupting binocular vision during a developmental critical period can yield enduring changes to ocular dominance (OD) in primary visual cortex (V1). Here we investigated how this experience-dependent plasticity is coordinated within the laminar circuitry of V1 by deleting separately in each cortical layer (L) a gene required to close the critical period, nogo-66 receptor (ngr1). Deleting ngr1 in excitatory neurons in L4, but not in L2/3, L5, or L6, prevented closure of the critical period, and adult mice remained sensitive to brief monocular deprivation. Intracortical disinhibition, but not thalamocortical disinhibition, accompanied this OD plasticity. Both juvenile wild-type mice and adult mice lacking ngr1 in L4 displayed OD plasticity that advanced more rapidly L4 than L2/3 or L5. Interestingly, blocking OD plasticity in L2/3 with the drug AM-251 did not impair OD plasticity in L5. We propose that L4 restricts disinhibition and gates OD plasticity independent of a canonical cortical microcircuit.

Citing Articles

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