All-or-none Disconnection of Pyramidal Inputs Onto Parvalbumin-positive Interneurons Gates Ocular Dominance Plasticity

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2021 Sep 11

PMID 34508001

Citations 8

Authors

Daniel Severin

Su Z Hong

Seung-Eon Roh

Shiyong Huang

Jiechao Zhou

Michelle C D Bridi

Ingie Hong

Sachiko Murase

Sarah Robertson

Rebecca P Haberman

Richard L Huganir

Michela Gallagher

Elizabeth M Quinlan

Paul Worley

Alfredo Kirkwood

Affiliations

Soon will be listed here.

Abstract

Disinhibition is an obligatory initial step in the remodeling of cortical circuits by sensory experience. Our investigation on disinhibitory mechanisms in the classical model of ocular dominance plasticity uncovered an unexpected form of experience-dependent circuit plasticity. In the layer 2/3 of mouse visual cortex, monocular deprivation triggers a complete, "all-or-none," elimination of connections from pyramidal cells onto nearby parvalbumin-positive interneurons (Pyr→PV). This binary form of circuit plasticity is unique, as it is transient, local, and discrete. It lasts only 1 d, and it does not manifest as widespread changes in synaptic strength; rather, only about half of local connections are lost, and the remaining ones are not affected in strength. Mechanistically, the deprivation-induced loss of Pyr→PV is contingent on a reduction of the protein neuropentraxin2. Functionally, the loss of Pyr→PV is absolutely necessary for ocular dominance plasticity, a canonical model of deprivation-induced model of cortical remodeling. We surmise, therefore, that this all-or-none loss of local Pyr→PV circuitry gates experience-dependent cortical plasticity.

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