Near-infrared Fluorescence Imaging in Immunotherapy

Overview

Journal Adv Drug Deliv Rev

Specialty Pharmacology

Date 2020 Jun 25

PMID 32579891

Citations 36

Authors

Yuanyuan Ji

Catherine Jones

Yoonji Baek

G Kate Park

Satoshi Kashiwagi

Hak Soo Choi

Affiliations

Soon will be listed here.

Abstract

Near-infrared (NIR) light possesses many suitable optophysical properties for medical imaging including low autofluorescence, deep tissue penetration, and minimal light scattering, which together allow for high-resolution imaging of biological tissue. NIR imaging has proven to be a noninvasive and effective real-time imaging methodology that provides a high signal-to-background ratio compared to other potential optical imaging modalities. In response to this, the use of NIR imaging has been extensively explored in the field of immunotherapy. To date, NIR fluorescence imaging has successfully offered reliable monitoring of the localization, dynamics, and function of immune responses, which are vital in assessing not only the efficacy but also the safety of treatments to design immunotherapies optimally. This review aims to provide an overview of the current research on NIR imaging of the immune response. We expect that the use of NIR imaging will expand further in response to the recent success in cancer immunotherapy. We will also offer our insights on how this technology will meet rapidly growing expectations in the future.

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