Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2020 Jun 25

PMID 32578163

Citations 4

Authors

Redin A Spann

Bernadette E Grayson

Affiliations

Soon will be listed here.

Abstract

Approximately 250,000 individuals seek bariatric surgery each year in the USA for the long-term resolution of obesity-related comorbidities. Greater than 80% of these individuals are women and approximately half are of child-bearing age. Although there are many positive metabolic benefits that are realized through surgical weight loss for both men and women, the various long-term hormonal, molecular, nutrient, and epigenetic changes following bariatric surgery have not been evaluated for the surgical recipient or in the context of pregnancy and the offspring. Pregnancy may be a vulnerable period of time for the bariatric surgery recipient, and thoughtful consideration of pregnancy management should be taken by health care providers and recipients alike. The purpose of this review is to explore potential etiologies of some of the gestation-specific outcomes for the mother and offspring.

Citing Articles

Altered Estrous Cyclicity and Feeding Neurocircuitry, but Not Cardiovascular Indices in Female Offspring from Dams with Previous Vertical Sleeve Gastrectomy Surgery.

Johnson S, Welch T, Aravindan N, Spann R, Welch B, Grayson B Brain Sci. 2023; 13(8).

PMID: 37626574 PMC: 10452692. DOI: 10.3390/brainsci13081218.

The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility.

Comas-Armangue G, Makharadze L, Gomez-Velazquez M, Teperino R Biomedicines. 2022; 10(10).

PMID: 36289722 PMC: 9599218. DOI: 10.3390/biomedicines10102461.

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys.

Kraynak M, Willging M, Kuehlmann A, Kapoor A, Flowers M, Colman R J Endocr Soc. 2022; 6(6):bvac063.

PMID: 35592515 PMC: 9113444. DOI: 10.1210/jendso/bvac063.

Dysregulated appetitive leptin signaling in male rodent offspring from post-bariatric dams.

Deer E, Phillips C, Welch B, Himel A, Duncan B, Spann R Curr Res Physiol. 2021; 3:50-58.

PMID: 33644768 PMC: 7909366. DOI: 10.1016/j.crphys.2020.11.002.

References

Catalano P, Shankar K . Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017; 356:j1. PMC: 6888512. DOI: 10.1136/bmj.j1. View

. ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2018; 133(1):1. DOI: 10.1097/AOG.0000000000003018. View

. Practice Bulletin No. 173: Fetal Macrosomia. Obstet Gynecol. 2016; 128(5):e195-e209. DOI: 10.1097/AOG.0000000000001767. View

Grayson B, Gutierrez-Aguilar R, Sorrell J, Matter E, Adams M, Howles P . Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling. Biol Sex Differ. 2017; 8:4. PMC: 5273842. DOI: 10.1186/s13293-017-0126-x. View

Mead N, Sakkatos P, Sakellaropoulos G, Adonakis G, Alexandrides T, Kalfarentzos F . Pregnancy outcomes and nutritional indices after 3 types of bariatric surgery performed at a single institution. Surg Obes Relat Dis. 2014; 10(6):1166-73. DOI: 10.1016/j.soard.2014.02.011. View

Faintuch J, Dias M, Fazio E, de Oliveira F, Nomura R, Zugaib M . Pregnancy nutritional indices and birth weight after Roux-en-Y gastric bypass. Obes Surg. 2008; 19(5):583-9. DOI: 10.1007/s11695-008-9755-9. View

Spinelli V, Lalloyer F, Baud G, Osto E, Kouach M, Daoudi M . Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans. Int J Obes (Lond). 2016; 40(8):1260-7. DOI: 10.1038/ijo.2016.46. View

Helmling S, Jarosch F, Klussmann S . The promise of ghrelin antagonism in obesity treatment. Drug News Perspect. 2006; 19(1):13-20. DOI: 10.1358/dnp.2006.19.1.965870. View

Warchol M, Wojciechowska M, Kupsz J, Sot-Szewczyk M, Michalak M, Kolodziejski P . Association of cord blood ghrelin, leptin and insulin concentrations in term newborns with anthropometric parameters at birth. J Pediatr Endocrinol Metab. 2018; 31(2):151-157. DOI: 10.1515/jpem-2017-0285. View

10.

Parent B, Martopullo I, Weiss N, Khandelwal S, Fay E, Rowhani-Rahbar A . Bariatric Surgery in Women of Childbearing Age, Timing Between an Operation and Birth, and Associated Perinatal Complications. JAMA Surg. 2016; 152(2):128-135. DOI: 10.1001/jamasurg.2016.3621. View

11.

Smith N, Hackett T, Galli A, Flynn C . GLP-1: Molecular mechanisms and outcomes of a complex signaling system. Neurochem Int. 2019; 128:94-105. PMC: 7081944. DOI: 10.1016/j.neuint.2019.04.010. View

12.

Cnattingius S, Villamor E, Johansson S, Edstedt Bonamy A, Persson M, Wikstrom A . Maternal obesity and risk of preterm delivery. JAMA. 2013; 309(22):2362-70. DOI: 10.1001/jama.2013.6295. View

13.

Rahman M, Abe S, Rahman M, Kanda M, Narita S, Bilano V . Maternal anemia and risk of adverse birth and health outcomes in low- and middle-income countries: systematic review and meta-analysis. Am J Clin Nutr. 2016; 103(2):495-504. DOI: 10.3945/ajcn.115.107896. View

14.

Forbes R, Gasevic D, Watson E, Ziegler T, Lin E, Burgess J . Essential Fatty Acid Plasma Profiles Following Gastric Bypass and Adjusted Gastric Banding Bariatric Surgeries. Obes Surg. 2015; 26(6):1237-46. DOI: 10.1007/s11695-015-1876-3. View

15.

Myronovych A, Kirby M, Ryan K, Zhang W, Jha P, Setchell K . Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obesity (Silver Spring). 2013; 22(2):390-400. PMC: 3836901. DOI: 10.1002/oby.20548. View

16.

Myronovych A, Salazar-Gonzalez R, Ryan K, Miles L, Zhang W, Jha P . The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice. Obesity (Silver Spring). 2014; 22(11):2301-11. PMC: 4286402. DOI: 10.1002/oby.20890. View

17.

Chambers A, Kirchner H, Wilson-Perez H, Willency J, Hale J, Gaylinn B . The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2012; 144(1):50-52.e5. PMC: 3752595. DOI: 10.1053/j.gastro.2012.09.009. View

18.

Santoro N, Lasley B, McConnell D, Allsworth J, Crawford S, Gold E . Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: The Study of Women's Health across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab. 2004; 89(6):2622-31. DOI: 10.1210/jc.2003-031578. View

19.

De Magalhaes Filho C, Downes M, Evans R . Farnesoid X Receptor an Emerging Target to Combat Obesity. Dig Dis. 2017; 35(3):185-190. PMC: 5417073. DOI: 10.1159/000450909. View

20.

Burstein E, Levy A, Mazor M, Wiznitzer A, Sheiner E . Pregnancy outcome among obese women: a prospective study. Am J Perinatol. 2008; 25(9):561-6. DOI: 10.1055/s-0028-1085623. View