GLP-1: Molecular Mechanisms and Outcomes of a Complex Signaling System

Overview

Journal Neurochem Int

Specialties Chemistry
Neurology

Date 2019 Apr 20

PMID 31002893

Citations 57

Authors

Nicholas K Smith

Troy A Hackett

Aurelio Galli

Charles R Flynn

Affiliations

Soon will be listed here.

Abstract

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.

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