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SARS CoV-2 Aggravates Cellular Metabolism Mediated Complications in COVID-19 Infection

Overview
Journal Dermatol Ther
Specialty Dermatology
Date 2020 Jun 20
PMID 32558055
Citations 26
Authors
Yogendra Singh
Gaurav Gupta
Imran Kazmi
Fahad A Al-Abbasi
Poonam Negi
Dinesh Kumar Chellappan
Kamal Dua
Affiliations
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Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.

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