» Articles » PMID: 32554057

Accelerated Miniature Swine Models of Advanced Atherosclerosis: A Review Based on Morphology

Overview
Date 2020 Jun 20
PMID 32554057
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

In order to accelerate development of atherosclerosis(AS) in miniature swine models, varieties of strategies and methods have been explored. In addition to traditional methods such as high cholesterol feeding and balloon injury, new methods such as familial hypercholesterolemia induced by gene editing and intramural injection have been applied in recent years. Although it has been claimed that these methods have successfully aggravated lesion areas and stenosis, lesion features induced by different strategies have shown heterogeneity in morphology. In addition, time consumption, high cost, and unavailability are problems that restrict application of these AS models. Here, we summarize strategies and methods to accelerate AS models and further analyze their values, advantages, and shortcomings.

Citing Articles

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries.

Vuong T, Bartolf-Kopp M, Andelovic K, Jungst T, Farbehi N, Wise S Adv Sci (Weinh). 2024; 11(26):e2307627.

PMID: 38704690 PMC: 11234431. DOI: 10.1002/advs.202307627.


Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine.

Kemper P, Karageorgos G, Fodera D, Lee N, Meshram N, Weber R Sci Rep. 2023; 13(1):6305.

PMID: 37072435 PMC: 10113229. DOI: 10.1038/s41598-023-32358-1.


Non-Mouse Models of Atherosclerosis: Approaches to Exploring the Translational Potential of New Therapies.

Kamato D, Ilyas I, Xu S, Little P Int J Mol Sci. 2022; 23(21).

PMID: 36361754 PMC: 9656683. DOI: 10.3390/ijms232112964.


Identification of Body Size Determination Related Candidate Genes in Domestic Pig Using Genome-Wide Selection Signal Analysis.

Pan B, Long H, Yuan Y, Zhang H, Peng Y, Zhou D Animals (Basel). 2022; 12(14).

PMID: 35883386 PMC: 9312078. DOI: 10.3390/ani12141839.


Multi-Omic Analysis in a Metabolic Syndrome Porcine Model Implicates Arachidonic Acid Metabolism Disorder as a Risk Factor for Atherosclerosis.

Xu S, Zhang X, Liu S, Feng S, Xiang G, Xu C Front Nutr. 2022; 9:807118.

PMID: 35284467 PMC: 8906569. DOI: 10.3389/fnut.2022.807118.