The Effects of Immunostimulatory Herbal Supplements on Autoimmune Skin Diseases

Overview

Journal J Am Acad Dermatol

Specialty Dermatology

Date 2020 Jun 20

PMID 32553683

Citations 14

Authors

Christina E Bax

Srita Chakka

Josef Symon S Concha

Majid Zeidi

Victoria P Werth

Affiliations

Soon will be listed here.

Abstract

The use of herbal supplements that promise to improve immune health has gained popularity among dermatology patients. However, there is little to no evidence that herbal supplements improve dermatologic conditions. Several in vitro and in vivo studies have shown that Spirulina platensis, Aphanizomenon flos-aqua, Chlorella, Echinacea, and alfalfa activate immune cells via certain cytokines and chemokines. Case reports suggest the association of ingesting immunostimulatory herbs and the clinical onset or flares of diseases characterized by an exaggerated immune response such as lupus erythematosus, dermatomyositis, and autoimmune blistering disorders. Therefore, it is imperative to investigate the prevalence of herbal supplement use in this patient population. In addition, in vitro studies should examine the underlying mechanisms by which herbs stimulate immune pathways that are already overactive in autoimmune patients.

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