Nasal Wash Cytokines During Respiratory Viral Infection in Pediatric Allogeneic Hematopoietic Cell-Transplant Recipients

Overview

Journal Am J Respir Cell Mol Biol

Specialties Cell Biology
Molecular Biology

Date 2020 Jun 20

PMID 32551899

Citations 2

Authors

Tim Flerlage

Aisha Souquette

E Kaitlynn Allen

Timothy Brahm

Jeremy Chase Crawford

Li Tang

Yilun Sun

Gabriela Maron

Joshua Wolf

Brandon Triplett

Paul G Thomas

Affiliations

Soon will be listed here.

Abstract

Allogeneic hematopoietic cell-transplant (alloHCT) recipients are at increased risk of complications from viral respiratory-tract infections (vRTIs). We measured cytokine concentrations in nasal washes (NWs) from pediatric alloHCT recipients to better understand their local response to vRTI. Forty-one immunologic analytes were measured in 70 NWs, collected during and after vRTI, from 15 alloHCT recipients (median age, 11 yr) with 19 episodes of vRTI. These were compared with NW cytokine concentrations from an independent group of otherwise healthy patients. AlloHCT recipients are able to produce a local response to vRTI and produce IFN-α2 and IL-12p40 in significant quantities above an uninfected baseline early in infection. Compared with otherwise healthy comparator-group patients, alloHCT recipients have higher NW concentrations of IL-4 when challenged with vRTI. Further study of these immunologic analytes as well as of type 1 versus type 2 balance in the respiratory mucosa in the context of vRTI during immune reconstitution may be of future research interest in this vulnerable patient population.

Citing Articles

Update in Pediatrics 2020.

Forno E, Abman S, Singh J, Robbins M, Selvadurai H, Schumacker P Am J Respir Crit Care Med. 2021; 204(3):274-284.

PMID: 34126039 PMC: 8513597. DOI: 10.1164/rccm.202103-0605UP.

Update in Critical Care 2020.

Khemani R, Lee J, Wu D, Schenck E, Hayes M, Kritek P Am J Respir Crit Care Med. 2021; 203(9):1088-1098.

PMID: 33734938 PMC: 8314915. DOI: 10.1164/rccm.202102-0336UP.

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