A Discrete Neuronal Circuit Induces a Hibernation-like State in Rodents

Overview

Journal Nature

Specialty Science

Date 2020 Jun 13

PMID 32528181

Citations 101

Authors

Tohru M Takahashi

Genshiro A Sunagawa

Shingo Soya

Manabu Abe

Katsuyasu Sakurai

Kiyomi Ishikawa

Masashi Yanagisawa

Hiroshi Hama

Emi Hasegawa

Atsushi Miyawaki

Kenji Sakimura

Masayo Takahashi

Takeshi Sakurai

Affiliations

Soon will be listed here.

Abstract

Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.

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