Abdominal Aortic Calcification in Predialysis Patients: Contribution of Traditional and Uremia-related Risk Factors

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2020 Jun 9

PMID 32509000

Citations 10

Authors

Delia Timofte

Dorin Dragos

Andra-Elena Balcangiu-Stroescu

Maria-Daniela Tanasescu

Daniela Gabriela Balan

Laura Raducu

Adrian Tulin

Ovidiu Stiru

Dorin Ionescu

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement of renal replacement therapy. Vascular calcifications (VC) and arterial stiffness are major contributors to cardiovascular disease and are independent predictors of cardiovascular mortality in ESRD patients. Scarce information is available on the risk factors and prognosis of predialysis patients with VC. The aim of this study was to evaluate the contribution of traditional and uremia related risk factors to abdominal aortic calcification in predialysis patients. A single center, retrospective study was performed on 305 adult patients monitored at the Bucharest University Emergency Hospital for at least 6 months. Our study reports an increased incidence of VC in predialysis chronic kidney disease (CKD) patients, higher in those with advanced age, history of cardiovascular disease, osteoporosis, and declining renal function.

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