Recent Advances in Modulators of Circadian Rhythms: an Update and Perspective

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2020 Jun 9

PMID 32506972

Citations 14

Authors

Shenzhen Huang

Xinwei Jiao

Dingli Lu

Xiaoting Pei

Di Qi

Zhijie Li

Affiliations

Soon will be listed here.

Abstract

Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna. Circadian alignment in humans has the greatest effect on human health, and circadian misalignment is closely associated with increased risk for metabolic syndrome, cardiovascular diseases, neurological diseases, immune diseases, cancer, sleep disorders, and ophthalmic diseases. The recent description of clock proteins and related post-modification targets was involved in several diseases, and numerous lines of evidence are emerging that small molecule modulators of circadian rhythms can be used to rectify circadian disorder. Herein, we attempt to update the disclosures about the modulators targeting core clock proteins and related post-modification targets, as well as the relationship between circadian rhythm disorders and human health as well as the therapeutic role and prospect of these small molecule modulators in circadian rhythm related disease.

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