Risk Factors for New-onset Diabetes Mellitus After Kidney Transplantation: A Systematic Review and Meta-analysis

Overview

Journal J Diabetes Investig

Specialty Endocrinology

Date 2020 Jun 8

PMID 32506801

Citations 15

Authors

Mancheng Xia

Haosen Yang

Xunan Tong

Hongjie Xie

Fan Cui

Weibing Shuang

Affiliations

Soon will be listed here.

Abstract

Aims/introduction: To systematically review the risk factors for new-onset diabetes mellitus after kidney transplantation, and to provide a theoretical basis for the prevention and management of new-onset diabetes mellitus after kidney transplantation.

Materials And Methods: We searched PubMed, Web of Science, Embase, the Cochrane Library databases and other databases for case-control studies related to risk factors for new-onset diabetes mellitus after kidney transplantation published between January 2005 and July 2019. A meta-analysis of data on risk factors for new-onset diabetes mellitus after kidney transplantation from the included studies was carried out. A narrative review of risk factors for new-onset diabetes mellitus after kidney transplantation was also carried out.

Results: A total of 24 case-control studies were included in the meta-analysis, with a total of 7,140 patients. There were 1,598 patients with new-onset diabetes mellitus after kidney transplantation, and 5,542 patients without new-onset diabetes mellitus after kidney transplantation. The meta-analysis results showed that age, polycystic kidney disease, family history of diabetes, body mass index, acute rejection, tacrolimus use, hepatitis B virus infection, hepatitis C virus infection and hypertension were associated with new-onset diabetes mellitus after kidney transplantation, whereas sex, sirolimus use, cyclosporin A use, steroid use and cytomegalovirus infection were not associated with new-onset diabetes mellitus after kidney transplantation.

Conclusions: Older age, body mass index, family history of diabetes, tacrolimus use, history of hypertension, polycystic kidney disease, acute rejection, hepatitis B virus infection and hepatitis C virus infection are risk factors for new-onset diabetes mellitus after kidney transplantation. Therefore, the clinical implications of these factors warrant attention.

Citing Articles

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Elevated Plasma High Sensitive C-Reactive Protein and Triglyceride/High-Density Lipoprotein Cholesterol Ratio are Risks Factors of Diabetes Progression in Prediabetes Patients After Kidney Transplant: A 3-Year Single-Center Study in Vietnam.

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Post-transplant diabetes mellitus: risk factors and outcomes in a 5-year follow-up.

Rossi M, Mazzali M, de Sousa M Front Clin Diabetes Healthc. 2024; 5:1336896.

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Postoperative fasting plasma glucose and family history diabetes mellitus can predict post-transplantation diabetes mellitus in kidney transplant recipients.

Wang L, Huang J, Li Y, Shi K, Gao S, Zhao W Endocrine. 2023; 81(1):58-66.

PMID: 37148416 DOI: 10.1007/s12020-023-03374-y.

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