Metabolic Characteristics of CD8 T Cell Subsets in Young and Aged Individuals Are Not Predictive of Functionality

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Jun 7

PMID 32504069

Citations 30

Authors

Kylie M Quinn

Tabinda Hussain

Felix Kraus

Luke E Formosa

Wai K Lam

Michael J Dagley

Eleanor C Saunders

Lisa M Assmus

Erica Wynne-Jones

Liyen Loh

Carolien E van de Sandt

Lucy Cooper

Kim L Good-Jacobson

Katherine Kedzierska

Laura K Mackay

Malcolm J McConville

Georg Ramm

Michael T Ryan

Nicole L La Gruta

Affiliations

Soon will be listed here.

Abstract

Virtual memory T (T) cells are antigen-naïve CD8 T cells that exist in a semi-differentiated state and exhibit marked proliferative dysfunction in advanced age. High spare respiratory capacity (SRC) has been proposed as a defining metabolic characteristic of antigen-experienced memory T (T) cells, facilitating rapid functionality and survival. Given the semi-differentiated state of T cells and their altered functionality with age, here we investigate T cell metabolism and its association with longevity and functionality. Elevated SRC is a feature of T, but not T, cells and it increases with age in both subsets. The elevated SRC observed in aged mouse T cells and human CD8 T cells from older individuals is associated with a heightened sensitivity to IL-15. We conclude that elevated SRC is a feature of T, but not T, cells, is driven by physiological levels of IL-15, and is not indicative of enhanced functionality in CD8 T cells.

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