Non-coding RNAs Shuttled Via Exosomes Reshape the Hypoxic Tumor Microenvironment

Overview

Journal J Hematol Oncol

Publisher Biomed Central

Specialties Hematology
Oncology

Date 2020 Jun 7

PMID 32503591

Citations 33

Authors

Wenyu Wang

Youngjin Han

Hyun A Jo

Juwon Lee

Yong Sang Song

Affiliations

Soon will be listed here.

Abstract

Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.

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References

Kuchuk O, Tuccitto A, Citterio D, Huber V, Camisaschi C, Milione M . pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma. Oncoimmunology. 2018; 7(7):e1445452. PMC: 5993489. DOI: 10.1080/2162402X.2018.1445452. View

Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki J . Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood. 2014; 124(25):3748-57. PMC: 4263983. DOI: 10.1182/blood-2014-05-576116. View

Bavelloni A, Ramazzotti G, Poli A, Piazzi M, Focaccia E, Blalock W . MiRNA-210: A Current Overview. Anticancer Res. 2017; 37(12):6511-6521. DOI: 10.21873/anticanres.12107. View

Wahlestedt C . Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov. 2013; 12(6):433-46. DOI: 10.1038/nrd4018. View

El Andaloussi S, Mager I, Breakefield X, Wood M . Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013; 12(5):347-57. DOI: 10.1038/nrd3978. View

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

Wegiel B, Vuerich M, Daneshmandi S, Seth P . Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy. Front Oncol. 2018; 8:284. PMC: 6099109. DOI: 10.3389/fonc.2018.00284. View

Vasconcelos M, Caires H, Abols A, Xavier C, Line A . Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance. Drug Resist Updat. 2019; 47:100647. DOI: 10.1016/j.drup.2019.100647. View

Daniel S, Sullivan K, Labadie K, Pillarisetty V . Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma. Clin Transl Med. 2019; 8(1):10. PMC: 6441665. DOI: 10.1186/s40169-019-0226-9. View

10.

Andersen S, Richardsen E, Moi L, Donnem T, Nordby Y, Ness N . Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer - a multicenter (in situ hybridization) study. Sci Rep. 2016; 6:36573. PMC: 5099893. DOI: 10.1038/srep36573. View

11.

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

12.

Tawadros A, Khalafalla M . Expression of programmed death-ligand 1 and hypoxia-inducible factor-1α proteins in endometrial carcinoma. J Cancer Res Ther. 2018; 14(Supplement):S1063-S1069. DOI: 10.4103/0973-1482.202891. View

13.

Wei J, Huang K, Yang C, Kang C . Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 2016; 37(1):3-9. DOI: 10.3892/or.2016.5236. View

14.

Pullan J, Confeld M, Osborn J, Kim J, Sarkar K, Mallik S . Exosomes as Drug Carriers for Cancer Therapy. Mol Pharm. 2019; 16(5):1789-1798. DOI: 10.1021/acs.molpharmaceut.9b00104. View

15.

Abraham J, Salama N, Azab A . The role of P-glycoprotein in drug resistance in multiple myeloma. Leuk Lymphoma. 2014; 56(1):26-33. DOI: 10.3109/10428194.2014.907890. View

16.

Li L, Cao B, Liang X, Lu S, Luo H, Wang Z . Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes. Oncogene. 2018; 38(15):2830-2843. DOI: 10.1038/s41388-018-0627-z. View

17.

Bardelli A, Pantel K . Liquid Biopsies, What We Do Not Know (Yet). Cancer Cell. 2017; 31(2):172-179. DOI: 10.1016/j.ccell.2017.01.002. View

18.

Henne W, Buchkovich N, Emr S . The ESCRT pathway. Dev Cell. 2011; 21(1):77-91. DOI: 10.1016/j.devcel.2011.05.015. View

19.

Suetsuna F, Harata S, Yoshimura N . Influence of the ultrasonic surgical aspirator on the dura and spinal cord. An electrohistologic study. Spine (Phila Pa 1976). 1991; 16(5):503-9. DOI: 10.1097/00007632-199105000-00003. View

20.

Booth A, Fang Y, Fallon J, Yang J, Hildreth J, Gould S . Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol. 2006; 172(6):923-35. PMC: 2063735. DOI: 10.1083/jcb.200508014. View