MiRNA-210: A Current Overview

Overview

Journal Anticancer Res

Specialty Oncology

Date 2017 Dec 1

PMID 29187425

Citations 130

Authors

Alberto Bavelloni

Giulia Ramazzotti

Alessandro Poli

Manuela Piazzi

Enrico Focaccia

William Blalock

Irene Faenza

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating evidence indicates that miRNAs contribute to tumorigenesis and cancer metastasis. microRNA-210 has been largely studied in the past several years and has been identified as a major miRNA induced under hypoxia. A variety of miR-210 targets have been identified pointing to its role, not only in mitochondrial metabolism, but also in angiogenesis, the DNA damage response, cell proliferation, and apoptosis. Based on earlier research findings, this review aims to provide a current overview on the involvement of miRNA-210 in biological processes and diseases.

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