Comprehensive Landscape of Extracellular Vesicle-derived RNAs in Cancer Initiation, Progression, Metastasis and Cancer Immunology

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2020 Jun 7

PMID 32503543

Citations 110

Authors

Wei Hu

Cong Liu

Zhuo-Yue Bi

Qun Zhou

Han Zhang

Lin-Lin Li

Jian Zhang

Wei Zhu

Yang-Yi-Yan Song

Feng Zhang

Hui-Min Yang

Yong-Yi Bi

Qi-Qiang He

Gong-Jun Tan

Cheng-Cao Sun

De-Jia Li

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane, respectively. EV-mediated bidirectional communication among various cell types supports cancer cell growth and metastasis. EVs derived from different cell types and status have been shown to have distinct RNA profiles, comprising messenger RNAs and non-coding RNAs (ncRNAs). Recently, ncRNAs have attracted great interests in the field of EV-RNA research, and growing numbers of ncRNAs ranging from microRNAs to long ncRNAs have been investigated to reveal their specific functions and underlying mechanisms in the tumor microenvironment and premetastatic niches. Emerging evidence has indicated that EV-RNAs are essential functional cargoes in modulating hallmarks of cancers and in reciprocal crosstalk within tumor cells and between tumor and stromal cells over short and long distance, thereby regulating the initiation, development and progression of cancers. In this review, we discuss current findings regarding EV biogenesis, release and interaction with target cells as well as EV-RNA sorting, and highlight biological roles and molecular mechanisms of EV-ncRNAs in cancer biology.

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