Translational Opportunities for Microfluidic Technologies to Enable Precision Epigenomics

Overview

Journal Anal Chem

Specialty Chemistry

Date 2020 Jun 5

PMID 32496751

Citations 3

Authors

Yi Xu

Steven R Doonan

Tamas Ordog

Ryan C Bailey

Affiliations

Soon will be listed here.

Abstract

Personalizing health care by taking genetic, environmental, and lifestyle factors into account is central to modern medicine. The crucial and pervasive roles epigenetic factors play in shaping gene-environment interactions are now well recognized. However, identifying robust epigenetic biomarkers and translating them to clinical tests has been difficult due in part to limitations of available platforms to detect epigenetic features genome-wide (epigenomic assays). This Feature introduces several important prospects for precision epigenomics, highlights capabilities and limitations of current laboratory technologies, and emphasizes opportunities for microfluidic tools to facilitate translation of epigenetic analyses to the clinic, with a particular focus on methods to profile gene-associated histone modifications and their impacts on chromatin structure and gene expression.

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