Ellagitannins and Simple Phenolics from the Halophytic Plant

Three new [nilotinins M8‒M10 (‒)] and two known [tamarixinin A () and gemin D ()] ellagitannins and seven simple phenolics [gallic acid (), methyl gallate (), 3,4-di--methylgallic acid (), ellagic acid (), 3--methylellagic acid (), methyl ferulate 3--sulphate (), and 7,4'-di--methylkaempferol ()] were isolated from the halophytic plant (Ehrenb.) Bunge (Tamaricaceae). Their structures were determined based on intensive spectroscopic studies and comparisons with reported data. Compounds , and - were evaluated for their cytotoxicity against lung adenocarcinoma cell line (A549) and anti-leishmanial activity against . Compounds , and showed promising cytotoxic properties against A549 (IC 29 ± 2.3, 10.5 ± 0.7, and 20.7 ± 1.9 μg/mL), while compounds and showed higher growth-inhibitory effects against promastigotes (IC 40.5 ± 2.7 and 38.4 ± 2.5 μg/mL), as compared with the standards doxorubicin (IC 0.42 µg/mL) and miltefosine (IC 9.43 μg/mL), respectively.