Activating Transcription Factor 3 Coordinates Differentiation of Cardiac and Hematopoietic Progenitors by Regulating Glucose Metabolism

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2020 Jun 5

PMID 32494702

Citations 4

Authors

Hui-Min Yin

Li-Feng Yan

Qian Liu

Zheng Peng

Chi-Yuan Zhang

Yu Xia

Dan Su

Ai-Hua Gu

Yong Zhou

Affiliations

Soon will be listed here.

Abstract

The cardiac and hematopoietic progenitors (CPs and HPs, respectively) in the mesoderm ultimately form a well-organized circulation system, but mechanisms that reconcile their development remain elusive. We found that activating transcription factor 3 () was highly expressed in the CPs, HPs, and mesoderm, in zebrafish. The mutants exhibited atrial dilated cardiomyopathy and a high ratio of immature myeloid cells. These manifestations were primarily caused by the blockade of differentiation of both CPs and HPs within the anterior lateral plate mesoderm. Mechanistically, Atf3 targets to repress -mediated glucose utilization. The high rate of glucose metabolism in mutants inhibited the differentiation of progenitors by changing the redox state. Therefore, could provide CPs and HPs with metabolic adaptive capacity to changes in glucose levels. Our study provides new insights into the role of in the coordination of differentiation of CPs and HPs by regulating glucose metabolism.

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