Alpha 2.0

» Articles » PMID: 32492245

Pericardial Fat Volume and Coronary Atherosclerotic Markers Among Body Mass Index Groups

Overview

Overview

Journal Clin Cardiol

Specialty Cardiology & Vascular Diseases

Date 2020 Jun 4

PMID 32492245

Citations 3

Authors

Authors

Mohammed Bader Hassan

Hussein Nafakhi

Abdulameer A Al-Mosawi

Affiliations

Affiliations

Soon will be listed here.

Abstract

Background: Increased pericardial fat volume (PFV) is associated with coronary atherosclerosis burden independent of body mass index (BMI) in many clinical studies. However, the association of PFV with markers of coronary atherosclerosis has not yet been assessed by dividing the patients according to BMI categories.

Hypothesis: To assess the association of PFV measured by multi-detector CT (MDCT) angiography with coronary atherosclerotic markers (coronary artery calcium score [CAC], plaque type, and luminal stenosis) among BMI categories.

Methods: A total of 496 patients with suspected coronary artery disease who underwent 64-slice MDCT angiography examination were enrolled. Patients divided into obese, overweight, and normal weight groups according to BMI degree.

Results: PFV showed a significant association with CAC, non-calcified coronary plaque, and significant coronary stenosis in obese group. After adjusting for cardiac risk factors, the association of PFV with the non-calcified coronary plaque and significant coronary stenosis persisted. There was a significant association between PFV with CAC and significant coronary stenosis in normal weight group. The association between PFV with CAC and significant coronary stenosis in normal weight was persisted afar adjusting for cardiac risk factors. No significant association was noted between PFV with coronary plaque type in normal weight group. There was no significant independent association between PFV with coronary atherosclerotic markers in overweight group.

Conclusions: Increased PFV was associated with advanced stage atherosclerosis in normal weight group, while increased PFV was associated with non-calcified plaque in obese. These results highlight the differential relationship of PFV with coronary atherosclerotic markers among BMI categories.

Citing Articles

Pericardial fat volume and coronary risk factors as predictors of non-calcified coronary plaque presence among patients with coronary calcium score = 0.

Al-Mosawi A, Nafakhi H, Alabayechi Y Indian Heart J. 2023; 76(1):51-53.

PMID: 38128878 PMC: 10943564. DOI: 10.1016/j.ihj.2023.12.006.

The Epigenetic Role of MiRNAs in Endocrine Crosstalk Between the Cardiovascular System and Adipose Tissue: A Bidirectional View.

Soci U, Cavalcante B, Improta-Caria A, Roever L Front Cell Dev Biol. 2022; 10:910884.

PMID: 35859891 PMC: 9289671. DOI: 10.3389/fcell.2022.910884.

Pericardial fat volume and coronary atherosclerotic markers among body mass index groups.

Hassan M, Nafakhi H, Al-Mosawi A Clin Cardiol. 2020; 43(9):993-998.

PMID: 32492245 PMC: 7462198. DOI: 10.1002/clc.23396.

References

1.

Ansaldo A, Montecucco F, Sahebkar A, Dallegri F, Carbone F . Epicardial adipose tissue and cardiovascular diseases. Int J Cardiol. 2018; 278:254-260. DOI: 10.1016/j.ijcard.2018.09.089. View

2.

Ismaeel H, Tellalian D, Hamirani Y, Kadakia J, Nasir K, Budoff M . Effect of obesity on coronary artery plaque using 64 slice multidetector cardiac computed tomography angiography. Int J Cardiol. 2009; 140(3):358-60. DOI: 10.1016/j.ijcard.2008.11.049. View

3.

Michos E, Choi A . Coronary Artery Disease in Young Adults: A Hard Lesson But a Good Teacher. J Am Coll Cardiol. 2019; 74(15):1879-1882. DOI: 10.1016/j.jacc.2019.08.1023. View

4.

Ferrara D, Montecucco F, Dallegri F, Carbone F . Impact of different ectopic fat depots on cardiovascular and metabolic diseases. J Cell Physiol. 2019; 234(12):21630-21641. DOI: 10.1002/jcp.28821. View

5.

Hastie C, Padmanabhan S, Slack R, Pell A, Oldroyd K, Flapan A . Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. Eur Heart J. 2009; 31(2):222-6. DOI: 10.1093/eurheartj/ehp317. View

6.

Lee H, Despres J, Kon Koh K . Perivascular adipose tissue in the pathogenesis of cardiovascular disease. Atherosclerosis. 2013; 230(2):177-84. DOI: 10.1016/j.atherosclerosis.2013.07.037. View

7.

Iwayama T, Nitobe J, Watanabe T, Ishino M, Tamura H, Nishiyama S . Role of epicardial adipose tissue in coronary artery disease in non-obese patients. J Cardiol. 2013; 63(5):344-9. DOI: 10.1016/j.jjcc.2013.10.002. View

8.

Bakkum M, Danad I, Romijn M, Stuijfzand W, Leonora R, Tulevski I . The impact of obesity on the relationship between epicardial adipose tissue, left ventricular mass and coronary microvascular function. Eur J Nucl Med Mol Imaging. 2015; 42(10):1562-73. PMC: 4521095. DOI: 10.1007/s00259-015-3087-5. View

9.

Bays H . Adiposopathy, "sick fat," Ockham's razor, and resolution of the obesity paradox. Curr Atheroscler Rep. 2014; 16(5):409. PMC: 3972445. DOI: 10.1007/s11883-014-0409-1. View

10.

Hassan M, Nafakhi H, Al-Mosawi A . Pericardial fat volume and coronary atherosclerotic markers among body mass index groups. Clin Cardiol. 2020; 43(9):993-998. PMC: 7462198. DOI: 10.1002/clc.23396. View

11.

Mancio J, Fonseca P, Figueiredo B, Ferreira W, Carvalho M, Ferreira N . Association of body mass index and visceral fat with aortic valve calcification and mortality after transcatheter aortic valve replacement: the obesity paradox in severe aortic stenosis. Diabetol Metab Syndr. 2017; 9:86. PMC: 5649084. DOI: 10.1186/s13098-017-0285-2. View

12.

Yong H, Kim E, Seo H, Kang E, Kim Y, Woo O . Pericardial fat is more abundant in patients with coronary atherosclerosis and even in the non-obese patients: evaluation with cardiac CT angiography. Int J Cardiovasc Imaging. 2009; 26 Suppl 1:53-62. DOI: 10.1007/s10554-009-9542-2. View

13.

Nafakhi H, Al-Mosawi A, Al-Nafakh H, Tawfeeq N . Association of pericardial fat volume with coronary atherosclerotic disease assessed by CT angiography. Br J Radiol. 2014; 87(1038):20130713. PMC: 4075553. DOI: 10.1259/bjr.20130713. View

14.

Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl U . Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2009; 29(5):781-6. DOI: 10.1161/ATVBAHA.108.180653. View

15.

Flegal K, Kit B, Orpana H, Graubard B . Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013; 309(1):71-82. PMC: 4855514. DOI: 10.1001/jama.2012.113905. View

16.

Bamberg F, Dannemann N, Shapiro M, Seneviratne S, Ferencik M, Butler J . Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography. Arterioscler Thromb Vasc Biol. 2008; 28(3):568-74. DOI: 10.1161/ATVBAHA.107.155010. View

17.

Levelt E, Pavlides M, Banerjee R, Mahmod M, Kelly C, Sellwood J . Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes. J Am Coll Cardiol. 2016; 68(1):53-63. PMC: 4925621. DOI: 10.1016/j.jacc.2016.03.597. View

18.

Park J, Ahn S, Hwang J, Lim H, Choi B, Choi S . Impact of body mass index on the relationship of epicardial adipose tissue to metabolic syndrome and coronary artery disease in an Asian population. Cardiovasc Diabetol. 2010; 9:29. PMC: 2913996. DOI: 10.1186/1475-2840-9-29. View

19.

Rodriguez-Granillo G, Carrascosa P, Deviggiano A, Capunay C, Zan M, Goldsmit A . Pericardial fat volume is related to atherosclerotic plaque burden rather than to lesion severity. Eur Heart J Cardiovasc Imaging. 2016; 18(7):795-801. DOI: 10.1093/ehjci/jew139. View

20.

Antonopoulos A, Tousoulis D . The molecular mechanisms of obesity paradox. Cardiovasc Res. 2017; 113(9):1074-1086. DOI: 10.1093/cvr/cvx106. View