Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2020 Jun 4

PMID 32490752

Citations 16

Authors

Larissa A Shimoda

Affiliations

Soon will be listed here.

Abstract

Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated pulmonary arterial pressure and, potentially, right heart failure. Vascular remodeling is an important contributor to the increased pulmonary vascular resistance. Hyperproliferation of smooth muscle, endothelial cells, and fibroblasts, and deposition of extracellular matrix lead to increased wall thickness, extension of muscle into normally non-muscular arterioles, and vascular stiffening. This review highlights intrinsic and extrinsic modulators contributing to the remodeling process.

Citing Articles

Transcriptome Analysis of Fibroblasts in Hypoxia-Induced Vascular Remodeling: Functional Roles of CD26/DPP4.

Suzuki Y, Kawasaki T, Tatsumi K, Okaya T, Sato S, Shimada A Int J Mol Sci. 2024; 25(23).

PMID: 39684311 PMC: 11640941. DOI: 10.3390/ijms252312599.

PI3K p85α/HIF-1α accelerates the development of pulmonary arterial hypertension by regulating fatty acid uptake and mitophagy.

Chen C, Qin S, Song X, Wen J, Huang W, Sheng Z Mol Med. 2024; 30(1):208.

PMID: 39528930 PMC: 11552344. DOI: 10.1186/s10020-024-00975-9.

Carotid Baroreceptor Stimulation Ameliorates Pulmonary Arterial Remodeling in Rats With Hypoxia-Induced Pulmonary Hypertension.

Fang X, Chen J, Hu Z, Shu L, Wang J, Dai M J Am Heart Assoc. 2024; 13(19):e035868.

PMID: 39344593 PMC: 11681457. DOI: 10.1161/JAHA.124.035868.

Roles of LncRNAs in the Pathogenesis of Pulmonary Hypertension.

Liu T, Xu S, Yang J, Xing X Rev Cardiovasc Med. 2024; 25(6):217.

PMID: 39076325 PMC: 11270120. DOI: 10.31083/j.rcm2506217.

The role of transcription factors in the pathogenesis and therapeutic targeting of vascular diseases.

Hu P, Du Y, Xu Y, Ye P, Xia J Front Cardiovasc Med. 2024; 11:1384294.

PMID: 38745757 PMC: 11091331. DOI: 10.3389/fcvm.2024.1384294.

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