» Articles » PMID: 15016901

Calcium and TRP Channels in Pulmonary Vascular Smooth Muscle Cell Proliferation

Overview
Specialty Physiology
Date 2004 Mar 16
PMID 15016901
Citations 49
Authors
Affiliations
Soon will be listed here.
Abstract

Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.

Citing Articles

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension.

Seidinger A, Roberts R, Bai Y, Muller M, Pfeil E, Matthey M EMBO Mol Med. 2024; 16(8):1930-1956.

PMID: 38977926 PMC: 11319782. DOI: 10.1038/s44321-024-00096-0.


The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca Entry in Pulmonary Arterial Smooth Muscle Cells.

Dai Z, Chen Y, Hsieh S, Yeh J, Hsu J, Wu B Pharmaceuticals (Basel). 2024; 17(4).

PMID: 38675401 PMC: 11053947. DOI: 10.3390/ph17040440.


[Quercetin improves pulmonary arterial hypertension in rats by regulating the HMGB1/RAGE/NF-κB pathway].

Zhang N, Qiu Q, Chen Y, Sun Z, Lu G, Wang L Nan Fang Yi Ke Da Xue Xue Bao. 2023; 43(9):1606-1612.

PMID: 37814876 PMC: 10563098. DOI: 10.12122/j.issn.1673-4254.2023.09.19.


Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension.

Zolty R J Exp Pharmacol. 2021; 13:817-857.

PMID: 34429666 PMC: 8380049. DOI: 10.2147/JEP.S236743.


Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment.

Mukherjee D, Konduri G Compr Physiol. 2021; 11(3):2135-2190.

PMID: 34190343 PMC: 8289457. DOI: 10.1002/cphy.c200023.