Successful Treatment of Painful Chronic Wounds with Amniotic and Umbilical Cord Tissue: A Case Series

Overview

Journal SAGE Open Med Case Rep

Publisher Sage Publications

Specialty General Medicine

Date 2020 Jun 2

PMID 32477550

Citations 1

Authors

Pablo Acevedo

Affiliations

Soon will be listed here.

Abstract

Patients with chronic wounds may experience persistent, debilitating pain that cannot be adequately managed with analgesics and that negatively impacts their quality of life. In this case series, three painful chronic and ischemic wounds that were caused by polyarteritis nodosa vasculitis ( = 1) and peripheral arterial disease (PAD) ( = 2) were successfully treated with cryopreserved umbilical cord tissue and/or amniotic membrane and umbilical cord particulate, resulting in notable reduction in pain within 7 days followed by expedited wound closure. No adverse events related to these tissue products were observed. These preliminary data demonstrate its safety and efficacy in reducing pain and promoting wound healing in painful chronic and ischemic wounds.

Citing Articles

Homologous Use of Allogeneic Umbilical Cord Tissue to Reduce Knee Pain and Improve Knee Function.

Timmons R, Sugaya K, Bane L Life (Basel). 2022; 12(2).

PMID: 35207547 PMC: 8876697. DOI: 10.3390/life12020260.

References

Woo K . Exploring the effects of pain and stress on wound healing. Adv Skin Wound Care. 2012; 25(1):38-44. DOI: 10.1097/01.ASW.0000410689.60105.7d. View

Kirsner R, Sabolinski M, Parsons N, Skornicki M, Marston W . Comparative effectiveness of a bioengineered living cellular construct vs. a dehydrated human amniotic membrane allograft for the treatment of diabetic foot ulcers in a real world setting. Wound Repair Regen. 2015; 23(5):737-44. DOI: 10.1111/wrr.12332. View

Mekkes J, Loots M, van der Wal A, Bos J . Causes, investigation and treatment of leg ulceration. Br J Dermatol. 2003; 148(3):388-401. DOI: 10.1046/j.1365-2133.2003.05222.x. View

Witherel C, Yu T, Concannon M, Dampier W, Spiller K . Immunomodulatory Effects of Human Cryopreserved Viable Amniotic Membrane in a Pro-Inflammatory Environment . Cell Mol Bioeng. 2017; 10(5):451-462. PMC: 5720175. DOI: 10.1007/s12195-017-0494-7. View

Benyamin R, Trescot A, Datta S, Buenaventura R, Adlaka R, Sehgal N . Opioid complications and side effects. Pain Physician. 2008; 11(2 Suppl):S105-20. View

Phillips T, Stanton B, Provan A, Lew R . A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol. 1994; 31(1):49-53. DOI: 10.1016/s0190-9622(94)70134-2. View

Eskandarlou M, Azimi M, Rabiee S, Seif Rabiee M . The Healing Effect of Amniotic Membrane in Burn Patients. World J Plast Surg. 2016; 5(1):39-44. PMC: 4904137. View

White R . Wound infection-associated pain. J Wound Care. 2009; 18(6):245-9. DOI: 10.12968/jowc.2009.18.6.42803. View

Nussbaum S, Carter M, Fife C, DaVanzo J, Haught R, Nusgart M . An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds. Value Health. 2018; 21(1):27-32. DOI: 10.1016/j.jval.2017.07.007. View

10.

Bechert K, Abraham S . Pain management and wound care. J Am Col Certif Wound Spec. 2014; 1(2):65-71. PMC: 3478916. DOI: 10.1016/j.jcws.2008.12.001. View

11.

Eriksson E, Hietanen H, Asko-Seljavaara S . Prevalence and characteristics of pressure ulcers. A one-day patient population in a Finnish city. Clin Nurse Spec. 2001; 14(3):119-25. DOI: 10.1097/00002800-200005000-00006. View

12.

Delgado A, McManus A, Chambers J . Exogenous administration of Substance P enhances wound healing in a novel skin-injury model. Exp Biol Med (Maywood). 2005; 230(4):271-80. DOI: 10.1177/153537020523000407. View

13.

Xue S, Liu K, Parolini O, Wang Y, Deng L, Huang Y . Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing. Burns Trauma. 2018; 6:34. PMC: 6297938. DOI: 10.1186/s41038-018-0136-x. View

14.

Purcell A, Buckley T, King J, Moyle W, Marshall A . Eutectic mixture of local anaesthetics (EMLA®) as a primary dressing on painful chronic leg ulcers: a pilot randomised controlled trial. Pilot Feasibility Stud. 2018; 4:123. PMC: 6035424. DOI: 10.1186/s40814-018-0312-6. View

15.

Williamson A, Hoggart B . Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005; 14(7):798-804. DOI: 10.1111/j.1365-2702.2005.01121.x. View

16.

Ribu L, Wahl A . Living with diabetic foot ulcers: a life of fear, restrictions, and pain. Ostomy Wound Manage. 2004; 50(2):57-67. View

17.

Tseng S . HC-HA/PTX3 Purified From Amniotic Membrane as Novel Regenerative Matrix: Insight Into Relationship Between Inflammation and Regeneration. Invest Ophthalmol Vis Sci. 2016; 57(5):ORSFh1-8. PMC: 4855828. DOI: 10.1167/iovs.15-17637. View

18.

Newbern S . Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. Adv Skin Wound Care. 2018; 31(3):102-108. DOI: 10.1097/01.ASW.0000530069.82749.e5. View

19.

Caputo W, Vaquero C, Monterosa A, Monterosa P, Johnson E, Beggs D . A retrospective study of cryopreserved umbilical cord as an adjunctive therapy to promote the healing of chronic, complex foot ulcers with underlying osteomyelitis. Wound Repair Regen. 2016; 24(5):885-893. DOI: 10.1111/wrr.12456. View

20.

Adly O, Moghazy A, Abbas A, Ellabban A, Ali O, Mohamed B . Assessment of amniotic and polyurethane membrane dressings in the treatment of burns. Burns. 2009; 36(5):703-10. DOI: 10.1016/j.burns.2009.09.003. View