The Healing Effect of Amniotic Membrane in Burn Patients

Overview

Journal World J Plast Surg

Specialty General Surgery

Date 2016 Jun 17

PMID 27308239

Citations 21

Authors

Mahdi Eskandarlou

Mina Azimi

Soghra Rabiee

Mohammad Ali Seif Rabiee

Affiliations

Soon will be listed here.

Abstract

Background: Different methods for dressing of donor site of skin graft in burn patients have similarly pain, limitation of mobility of donor site and local complications such as infection and scar. Amniotic membrane has used for improvement of healing in some wounds. Accordingly in this study amnion was used as biologic dressing for donor site of skin graft to evaluate it's efficacy in improvement of pain, move score and the risk of local infection.

Methods: Study was done as clinical trial over 32 admitted patients in burn department of Beasat hospital. Amnion was prepared in elective caesarean section after rule out any placental site for risk of torch and viral infection. Skin graft was taken from two sites in every patient. One site dressed with amnion and another with routine dressing. Then two sites were compared about severity of pain, move score, infection and time of dressing sloughing.

Results: Fourteen patients were women and 18 men. Mean score of pain and movement up to fourth and fifth post operative day respectively was less than control site. No difference is seen about infection and dressing slough in two sites.

Conclusion: It seems use of amnion for dressing of donor site probably cause rapid epithelialisation and wound healing and can improve pain and move score in early post operative days. Accordingly it is expected to need less analgesia and low rate of immobilization and following complications and earlier discharge of patients.

Citing Articles

Management of Foot Ulcers and Chronic Wounds with Amniotic Membrane in Comorbid Patients: A Successful Experience.

Rodriguez-Valiente M, Garcia-Hernandez A, Fuente-Mora C, Sanchez-Galvez J, Garcia-Vizcaino E, Tristante Barrenechea E Biomedicines. 2024; 12(10).

PMID: 39457692 PMC: 11505069. DOI: 10.3390/biomedicines12102380.

The impact of an open-label design on human amniotic membranes vs. silver sulfadiazine dressings for second-degree burns: a randomized controlled clinical trial.

Moghimi M, Salehian M, Abdi M, Tahrekhani M, Safaei A, Kamali K BMC Surg. 2024; 24(1):309.

PMID: 39396946 PMC: 11472429. DOI: 10.1186/s12893-024-02554-5.

Creation of neovagina in women with Müllerian agenesis (Mayer-Rokitansky-Küster-Hauser syndrome) using fresh human amnion.

Gari A, Baradwan S, Iskandarani R, Alkhiary A, Abumohssin A, Abu-Zaid A Obstet Gynecol Sci. 2024; 67(6):541-549.

PMID: 39318165 PMC: 11581817. DOI: 10.5468/ogs.24114.

Outcome of Application of Cryopreserved Amniotic Membrane Grafts in the Treatment of Chronic Nonhealing Wounds of Different Origins in Polymorbid Patients: A Prospective Multicenter Study.

Svobodova A, Horvath V, Balogh L, Zemlickova M, Fiala R, Burkert J Bioengineering (Basel). 2023; 10(8).

PMID: 37627785 PMC: 10451957. DOI: 10.3390/bioengineering10080900.

Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane.

Vrkoslav V, Smeringaiova I, Smorodinova N, Svobodova A, Strnad S, Jackson C Bioengineering (Basel). 2023; 10(6).

PMID: 37370671 PMC: 10294941. DOI: 10.3390/bioengineering10060740.

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