The Landmark Series: Gallbladder Cancer

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2020 Jun 1

PMID 32474816

Citations 21

Authors

Adriana C Gamboa

Shishir K Maithel

Affiliations

Soon will be listed here.

Abstract

Given the rarity of gallbladder carcinoma, level I evidence to guide the multimodal treatment of this disease is lacking. Since 2010, four randomized phase III clinical trials including ABC-02, PRODIGE-12/ACCORD-18, BILCAP, and BCAT, and a single-arm phase II trial (SWOG0809) have been reported on the use of adjuvant strategies for biliary malignancies. These trials have led to the recommendation that patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy and those with R1 margins could be considered for chemoradiotherapy. Because there is no level I evidence to guide neoadjuvant therapy or surgical management, current consensus is based on strong retrospective data. The following review summarizes available trials and highlights the best available evidence that form the basis of consensus statements for the multimodal management of gallbladder carcinoma.

Citing Articles

Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis.

Zhang L, Wang K, Liu R, Kuang T, Chen C, Yao F Nutr J. 2024; 23(1):145.

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Efficacy and predictors of immune checkpoint inhibitors in patients with gallbladder cancer.

Cheng Z, Yang C, Zhao Q, Zhong J, Zhang J, Jin R Cancer Sci. 2024; 115(6):1979-1988.

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Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis.

Kim M, Stroever S, Aploks K, Ostapenko A, Dong X, Seshadri R World J Gastrointest Surg. 2024; 16(1):95-102.

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New trends in diagnosis and management of gallbladder carcinoma.

Pavlidis E, Galanis I, Pavlidis T World J Gastrointest Oncol. 2024; 16(1):13-29.

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Adenosquamous carcinoma of the gallbladder: a rare entity and dilemmas in its management.

Zishan M, Tee C BMJ Case Rep. 2023; 16(5).

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