Introductions and Early Spread of SARS-CoV-2 in the New York City Area

Overview

Journal Science

Specialty Science

Date 2020 May 31

PMID 32471856

Citations 245

Authors

Ana S Gonzalez-Reiche

Matthew M Hernandez

Mitchell J Sullivan

Brianne Ciferri

Hala Alshammary

Ajay Obla

Shelcie Fabre

Giulio Kleiner

Jose Polanco

Zenab Khan

Bremy Alburquerque

Adriana van de Guchte

Jayeeta Dutta

Nancy Francoeur

Betsaida Salom Melo

Irina Oussenko

Gintaras Deikus

Juan Soto

Shwetha Hara Sridhar

Ying-Chih Wang

Kathryn Twyman

Andrew Kasarskis

Deena R Altman

Melissa Smith

Robert Sebra

Judith Aberg

Florian Krammer

Adolfo Garcia-Sastre

Marta Luksza

Gopi Patel

Alberto Paniz-Mondolfi

Melissa Gitman

Emilia Mia Sordillo

Viviana Simon

Harm van Bakel

Affiliations

Soon will be listed here.

Abstract

New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.

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